{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T11:40:12Z","timestamp":1722339612022},"reference-count":0,"publisher":"Wiley","issue":"1-2","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Analytical Cellular Pathology"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>: Chromosomal translocations are causally related to the development of many tumors. In Burkitt\u2032s lymphoma, abnormalities involving the c\u2010myc gene are essential. The CT\u2010element of the c\u2010myc promoter adopts non\u2010B\u2010conformation in vivo and in vitro, and therefore provides a potential fragile site. <jats:italic>Methods<\/jats:italic>: We have developed a LM\u2010PCR\u2010based approach to test if chromosomal breakpoints indeed cluster in this region. <jats:italic>Results<\/jats:italic>: Amplifying both, wild\u2010type as well as the translocated c\u2010myc gene by LM\u2010PCR, it was shown that chromosomal breakpoints did not cluster within the CT\u2010element. Conclusions: Therefore, the CT\u2010element is not especially susceptible to the formation of breakpoints leading to chromosomal translocations in Burkitt\u2032s lymphoma.<\/jats:p>","DOI":"10.1155\/2006\/695262","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T17:06:46Z","timestamp":1611248806000},"page":"31-35","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The CT\u2010Element of The C\u2010Myc Gene Does Not Predispose to Chromosomal Breakpoints in Burkitt\u2032S Lymphoma"],"prefix":"10.1155","volume":"28","author":[{"given":"Achim","family":"Weber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina I.","family":"Gutierrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Levens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1]]},"container-title":["Analytical Cellular Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/acp\/2006\/695262.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2006\/695262","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T11:11:32Z","timestamp":1722337892000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2006\/695262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":0,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["10.1155\/2006\/695262"],"URL":"https:\/\/doi.org\/10.1155\/2006\/695262","archive":["Portico"],"relation":{},"ISSN":["2210-7177","2210-7185"],"issn-type":[{"type":"print","value":"2210-7177"},{"type":"electronic","value":"2210-7185"}],"subject":[],"published":{"date-parts":[[2006,1]]},"assertion":[{"value":"2006-01-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}