{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:13:59Z","timestamp":1788869639533,"version":"build-2803163510"},"reference-count":0,"publisher":"Wiley","issue":"5-6","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001325","name":"Cancer Association of South Africa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:p>\n                    Polymorphisms in the promoter region of the Cytochrome P4502E1 (\n                    <jats:italic>CYP2E1<\/jats:italic>\n                    ) gene reportedly modify the metabolic activity of CYP2E1 enzyme, and have been associated with increased susceptibility to squamous cell carcinoma (SCC) of the oesophagus in high prevalence areas such as China. To assess the frequency of these polymorphisms in Black South Africans, a population with a high incidence of oesophageal SCC, this study examined genomic DNA from 331 subjects for restriction fragment length polymorphisms in the\n                    <jats:italic>CYP2E1<\/jats:italic>\n                    (\n                    <jats:italic>RsaI<\/jats:italic>\n                    and\n                    <jats:italic>PstI<\/jats:italic>\n                    digestion). The frequency of the\n                    <jats:italic>CYP2E1<\/jats:italic>\n                    c1\/c1 and c1\/c3 genotypes was 95% and 5% respectively. The frequency of the\n                    <jats:italic>CYP2E1<\/jats:italic>\n                    allele distribution was found to be markedly different between Chinese and South African populations; hence it is important to place racial differences into consideration when proposing allelic variants as genetic markers for cancer.\n                  <\/jats:p>","DOI":"10.1155\/2006\/980392","type":"journal-article","created":{"date-parts":[[2013,6,13]],"date-time":"2013-06-13T07:33:36Z","timestamp":1371108816000},"page":"351-354","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The Frequency of Cytochrome\n                    <i>P<\/i>\n                    450 2\n                    <i>E<\/i>\n                    1 Polymorphisms in Black South Africans"],"prefix":"10.1155","volume":"22","author":[{"given":"Paul K.","family":"Chelule","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary J.","family":"Pegoraro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nceba","family":"Gqaleni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael F.","family":"Dutton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,9]]},"container-title":["Disease Markers"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2006\/980392.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2006\/980392","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T16:49:53Z","timestamp":1723049393000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2006\/980392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":0,"journal-issue":{"issue":"5-6","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["10.1155\/2006\/980392"],"URL":"https:\/\/doi.org\/10.1155\/2006\/980392","archive":["Portico"],"relation":{},"ISSN":["0278-0240","1875-8630"],"issn-type":[{"value":"0278-0240","type":"print"},{"value":"1875-8630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1]]},"assertion":[{"value":"2007-01-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-01-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-06-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}