{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:46:36Z","timestamp":1788306396169,"version":"build-2803163510"},"reference-count":0,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Gastroenterology"],"published-print":{"date-parts":[[2007]]},"abstract":"INTRODUCTION: Genetic polymorphisms in apolipoprotein genes may be associated with alteration in lipid profile and susceptibility to gallstone disease.<\/jats:p>AIM: To determine the association betweenapolipoprotein A1<\/jats:italic>(APOA1<\/jats:italic>) (\u221275 guanine [G] to adenine [A] and +83\/84 M2+\/\u2212<\/jats:sup>,MspI<\/jats:italic>) andapolipoprotein C3<\/jats:italic>(APOC3<\/jats:italic>) (SstI<\/jats:italic>) polymorphisms with gallstone disease.<\/jats:p>METHODS:MspI<\/jats:italic>polymorphisms of theAPOA1<\/jats:italic>gene andSstI<\/jats:italic>polymorphisms ofAPOC3<\/jats:italic>were analyzed in DNA samples of 214 gallstone patients and 322 age- and sex-matched healthy controls. All statistical analyses were performed using SPSS version 11.5 (SPSS, USA) and Arlequin version 2.0 (Arlequin, Switzerland).<\/jats:p>RESULTS: TheAPOA1<\/jats:italic>\u221275 G\/A polymorphism was significantly associated with gallstone disease. Patients with the GG genotype (P=0.015) and G allele carriers (P=0.004) had a significantly higher risk of gallstone disease (1.087-fold and 1.561-fold, respectively), whereas patients with AA genotypes (P=0.011) and A allele carriers (P=0.004) were protected (OR 0.230 and 0.641, respectively) against gallstone disease.APOA1<\/jats:italic>+83 M2+\/\u2212<\/jats:sup>andAPOC3 SstI<\/jats:italic>polymorphisms were not associated with gallstone disease. Case-control analysis of haplotypes showed a significant association in males only. G-M2+<\/jats:sup>-S1 conferred risk for gallstone disease (P=0.036; OR 1.593, 95% CI 1.029 to 2.464), while A-M2+<\/jats:sup>-S1 was protective (P=0.002; OR 0.370, 95% CI 0.197 to 0.695) against gallstone disease. InAPOA1<\/jats:italic>\u221275<\/jats:sup>-APOA1<\/jats:italic>+83<\/jats:sup>bilocus haplotypes, G-M2+<\/jats:sup>was associated (P=0.0001) with very high risk (OR 3.173, 95% CI 1.774 to 5.674) for gallstone disease in males only.APOA1<\/jats:italic>\u221275<\/jats:sup>-APOC3SstI<\/jats:sup><\/jats:italic>haplotypes also showed significant association whileAPOA1<\/jats:italic>+83<\/jats:sup>-APOC3SstI<\/jats:sup><\/jats:italic>haplotypes showed no association with gallstone disease.<\/jats:p>CONCLUSIONS: TheAPOA1<\/jats:italic>\u221275 G\/A polymorphism is associated with gallstone disease and shows sex-specific differences. On the other hand,APOA1<\/jats:italic>M2+\/\u2212<\/jats:sup>andAPOC3 SstI<\/jats:italic>polymorphisms may not be associated with gallstone disease. Haplotype analysis is a better predictor of risk for gallstone disease.<\/jats:p>","DOI":"10.1155\/2007\/329342","type":"journal-article","created":{"date-parts":[[2016,3,15]],"date-time":"2016-03-15T03:54:22Z","timestamp":1458014062000},"page":"569-575","source":"Crossref","is-referenced-by-count":23,"title":["Association ofApolipoprotein A1-C3<\/i>Gene Cluster Polymorphisms with Gallstone Disease"],"prefix":"10.1155","volume":"21","author":[{"given":"Manjusha","family":"Dixit","sequence":"first","affiliation":[{"name":"Department of Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gourdas","family":"Choudhuri","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajan","family":"Saxena","sequence":"additional","affiliation":[{"name":"Department of Surgical Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balraj","family":"Mittal","sequence":"additional","affiliation":[{"name":"Department of Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","container-title":["Canadian Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2007\/329342.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2007\/329342.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T03:58:48Z","timestamp":1471924728000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/cjgh\/2007\/329342\/abs\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2007]]}},"alternative-id":["329342"],"URL":"https:\/\/doi.org\/10.1155\/2007\/329342","relation":{},"ISSN":["0835-7900"],"issn-type":[{"value":"0835-7900","type":"print"}],"subject":[],"published":{"date-parts":[[2007]]}}}