{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:42:53Z","timestamp":1791175373288,"version":"4.1.0"},"reference-count":0,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Analytical Cellular Pathology"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>: Peptide receptors, overexpressed in specific cancers, represent new diagnostic and therapeutic targets. In this study, receptors for the gastrin\u2010releasing peptide (GRP), and other members of the bombesin\u2010family of peptides, were evaluated in ovarian neoplasms. <jats:italic>Methods<\/jats:italic>: 75 primary, secondary and metastatic ovarian tumors were investigated for their bombesin\u2010receptor subtype expression, incidence, localization and density using <jats:italic>in vitro<\/jats:italic> autoradiography on tissue sections with the universal radioligand <jats:sup>125<\/jats:sup>I\u2010[D\u2010Tyr<jats:sup>6<\/jats:sup>, \u00df\u2010Ala<jats:sup>11<\/jats:sup>, Phe<jats:sup>13<\/jats:sup>, Nle<jats:italic>14<\/jats:italic>]\u2010bombesin(6\u201014) and the GRP\u2010receptor subtype\u2010preferring <jats:sup>125<\/jats:sup>I\u2010[Tyr<jats:sup>4<\/jats:sup>]\u2010bombesin. <jats:italic>Results<\/jats:italic>: GRP\u2010receptors were detected in 42\/61 primary ovarian tumors; other bombesin\u2010receptor subtypes (BB1, bb3) were rarely present (3\/61). Two different tissue compartments expressed GRP\u2010receptors: the tumoral vasculature was the predominant site of GRP\u2010receptor expression (38\/61), whereas neoplastic cells more rarely expressed GRP\u2010receptors (14\/61). GRP\u2010receptor positive vessels were present in the various classes of ovarian tumors; generally, malignant tumors had a higher incidence of GRP\u2010receptor positive vessels compared to their benign counterparts. The prevalence of such vessels was particularly high in ovarian carcinomas (16\/19) and their metastases (5\/5). The GRP\u2010receptors were expressed in high density in the muscular vessel wall. Normal ovary (<jats:italic>n<\/jats:italic>=10) lacked GRP\u2010receptors. <jats:italic>Conclusions<\/jats:italic>: The large amounts of GRP\u2010receptors in ovarian tumor vessels suggest a role in tumoral vasculature and possibly angiogenesis. Further, these vessels might be targeted <jats:italic>in vivo<\/jats:italic> with bombesin analogs for diagnosis or for therapy.<\/jats:p>","DOI":"10.1155\/2007\/798790","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T17:31:33Z","timestamp":1611250293000},"page":"421-433","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Overexpression of Gastrin\u2010Releasing Peptide Receptors in Tumor\u2010Associated Blood Vessels of Human Ovarian Neoplasms"],"prefix":"10.1155","volume":"29","author":[{"given":"Achim","family":"Fleischmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Waser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Claude","family":"Reubi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,1]]},"container-title":["Analytical Cellular Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/acp\/2007\/798790.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2007\/798790","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T15:41:54Z","timestamp":1722354114000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2007\/798790"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1155\/2007\/798790"],"URL":"https:\/\/doi.org\/10.1155\/2007\/798790","archive":["Portico"],"relation":{},"ISSN":["2210-7177","2210-7185"],"issn-type":[{"value":"2210-7177","type":"print"},{"value":"2210-7185","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1]]},"assertion":[{"value":"2007-01-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}