{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T02:11:57Z","timestamp":1791771117361,"version":"4.3.4"},"reference-count":32,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neural Plasticity"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>Tinnitus, the perception of sound in the absence of external acoustic stimulation, is a common and devastating pathology. It is often a consequence of acoustic trauma or drug toxicity. The neuronal mechanisms of tinnitus are neither yet fully understood nor are effective treatments available. Using a novel behavioral paradigm for measuring tinnitus in the rat based on tone-guided navigation, we show here that the development of long-term noise-induced tinnitus, the most prevalent and clinically important form of human tinnitus, can be abated by local administration of the NMDA antagonist \u201cifenprodil\u201d into the cochlea in the first 4 days following the noise insult but not afterwards. This suggests that long-term tinnitus undergoes a consolidation-like process, resembling the ontogeny of items in long-term memory. Furthermore, this finding paves the way to potential therapeutic strategies for the prevention of chronic tinnitus once the noise insult had taken place.<\/jats:p>","DOI":"10.1155\/2007\/80904","type":"journal-article","created":{"date-parts":[[2008,2,14]],"date-time":"2008-02-14T09:59:36Z","timestamp":1202983176000},"page":"1-11","source":"Crossref","is-referenced-by-count":65,"title":["Blockade of Cochlear NMDA Receptors Prevents Long-Term Tinnitus during a Brief Consolidation Window after Acoustic Trauma"],"prefix":"10.1155","volume":"2007","author":[{"given":"Matthieu J.","family":"Guitton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yadin","family":"Dudai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"issue":"3-4","key":"3","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1159\/000313202","volume":"5","year":"1995","journal-title":"Oto-Rhino-Laryngologia Nova"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.2174\/157340006778018139"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.3109\/00206098409070084"},{"issue":"1","key":"6","first-page":"37","volume":"8","year":"2002","journal-title":"International Tinnitus Journal"},{"issue":"9","key":"7","doi-asserted-by":"crossref","first-page":"3944","DOI":"10.1523\/JNEUROSCI.23-09-03944.2003","volume":"23","year":"2003","journal-title":"Journal of Neuroscience"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2004.08.010"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6446(05)03542-7"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2005.02.013"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1080\/00016489950181611"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.04436.x"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1037\/\/0735-7044.102.6.811"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90210-0"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1038\/377115a0"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.19.10457"},{"issue":"13","key":"17","doi-asserted-by":"crossref","first-page":"5129","DOI":"10.1523\/JNEUROSCI.17-13-05129.1997","volume":"17","year":"1997","journal-title":"Journal of Neuroscience"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1038\/43432"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00004-0"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(00)00027-7"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(02)00343-X"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.3109\/00206098309072795"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1121\/1.1910600"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(03)00296-9"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1080\/16513860410027394"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1038\/nn796"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1999.7135"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)01307-4"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5451.248"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.psych.55.090902.142050"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1126\/science.293.5531.755a"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5494.1170"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4381-05.2006"},{"key":"34","volume-title":"To consolidate or not to consolidate: what are the questions?","year":"2000"}],"container-title":["Neural Plasticity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/np\/2007\/080904.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/np\/2007\/080904.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T22:25:47Z","timestamp":1557267947000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/np\/2007\/080904\/abs\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":32,"alternative-id":["080904","80904"],"URL":"https:\/\/doi.org\/10.1155\/2007\/80904","relation":{},"ISSN":["2090-5904","1687-5443"],"issn-type":[{"value":"2090-5904","type":"print"},{"value":"1687-5443","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}