{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:49:30Z","timestamp":1773622170145,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Analytical Cellular Pathology"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>: Cell cycle proteins and HIF\u20101<jats:italic>\u03b1<\/jats:italic> with downstream factors are often abberrantly expressed in (pre)neoplastic tissue. <jats:italic>Methods<\/jats:italic>: Paraffin\u2010embedded specimens of inactive endometrium with TM (<jats:italic>n<\/jats:italic>=15), ovarian inclusion cysts (<jats:italic>n<\/jats:italic>=6), cervix with TM (tubal metaplasia) (<jats:italic>n<\/jats:italic>=3), Fallopian tubes (<jats:italic>n<\/jats:italic>=7), cycling endometrium (<jats:italic>n<\/jats:italic>=9) and a ciliated cell tumor of the ovary were stained for p16 and LhS28. 39 Endometrioid endometrial carcinomas and 5 serous endometrial carcinomas were stained for p16. Additionally, inactive endometrium (<jats:italic>n<\/jats:italic>=15) was immunohistochemically stained for p21, p27, p53, cyclin A, cyclin D1, cyclin E, HIF\u20101<jats:italic>\u03b1<\/jats:italic>, CAIX, Glut\u20101 and MIB\u20101. <jats:italic>Results<\/jats:italic>: A mosaic pattern of expression of p16 was seen throughout in all cases of endometrial TM (15\/15), in 2\/6 of the ovarian inclusion cysts with TM, in all (3\/3) cervical TM and focal in 5\/7 of Fallopian tube cases. Mosaic expression was also seen in a ciliated cell tumor of the ovary and in 18\/39 of endometrioid endometrial carcinomas, and diffuse p16 expression was seen in 5\/5 serous carcinomas. In comparison with normal endometrium, TM areas in the endometrium showed significantly increased expression of HIF\u20101<jats:italic>\u03b1<\/jats:italic>, cyclin E, p21 and cyclin A, and decreased expression of p27. Membranous expression of CAIX and Glut\u20101 was only seen in TM areas, pointing to functional HIF\u20101<jats:italic>\u03b1<\/jats:italic>. <jats:italic>Conclusion<\/jats:italic>: As p16 is consistently expressed in TM, less and only patchy expressed in the normal Fallopian tube, is paralleled by aberrant expression of cell cycle proteins, HIF\u20101<jats:italic>\u03b1<\/jats:italic>, CAIX and Glut\u20101 and resembles the pattern of p16 expression frequently seen in endometrial carcinomas, we propose endometrial TM to be a potential premalignant endometrial lesion.<\/jats:p>","DOI":"10.1155\/2007\/868952","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T17:37:07Z","timestamp":1611250627000},"page":"37-45","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["p16 is Consistently Expressed in Endometrial Tubal Metaplasia"],"prefix":"10.1155","volume":"29","author":[{"given":"N.","family":"Horree","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. P. M.","family":"Heintz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. M. D. S.","family":"Sie-Go","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.J.","family":"van Diest","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,1]]},"container-title":["Analytical Cellular Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/acp\/2007\/868952.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2007\/868952","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T12:52:36Z","timestamp":1722343956000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2007\/868952"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1155\/2007\/868952"],"URL":"https:\/\/doi.org\/10.1155\/2007\/868952","archive":["Portico"],"relation":{},"ISSN":["2210-7177","2210-7185"],"issn-type":[{"value":"2210-7177","type":"print"},{"value":"2210-7185","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1]]},"assertion":[{"value":"2007-01-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}