{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T19:28:25Z","timestamp":1774466905771,"version":"3.50.1"},"reference-count":38,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Minist\u00e8re de l\u2019Enseignement Sup\u00e9rieur et de la Recherche of Tunisia"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p><jats:italic>Objective and background<\/jats:italic>. Pulmonary aneurysms and thrombosis constitute a significant cause of morbidity and mortality in Beh\u00e7et's disease (BD). Various factors have been studied to explore the pathogenesis of vascular involvement in BD. As endothelin (ET) is known for its potent vasoconstrictor and proinflammatory properties, we supposed that it is involved during the inflammatory process of BD pulmonary vasculitis.<jats:italic>Methods<\/jats:italic>. To investigate the role of ET in BD, ET-1 concentrations were measured in bronchoalveolar lavage fluid (BALF) of 18 nonsmoking BD patients with pulmonary manifestations and 12 control subjects. Immunoreactivity of ET-1 was also evaluated in alveolar macrophages (AMs) cytoplasm.<jats:italic>Results<\/jats:italic>. ET-1 levels in BD-BALF were significantly higher than those of controls. ET-1 levels were correlated with the number of alveolar macrophages, but not with BAL-CD4\/CD8 ratio. ET-1-immunoreactivity was found mainly in AM of BD-BAL.<jats:italic>Conclusions<\/jats:italic>. 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