{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:38:31Z","timestamp":1753886311391,"version":"3.41.2"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,8,21]],"date-time":"2008-08-21T00:00:00Z","timestamp":1219276800000},"content-version":"vor","delay-in-days":233,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI 48474","R21AI59064"],"award-info":[{"award-number":["R01AI 48474","R21AI59064"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI 48474","R21AI59064"],"award-info":[{"award-number":["R01AI 48474","R21AI59064"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000046","name":"National Research Council Canada","doi-asserted-by":"publisher","award":["R01AI 48474","R21AI59064"],"award-info":[{"award-number":["R01AI 48474","R21AI59064"]}],"id":[{"id":"10.13039\/501100000046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2008,1]]},"abstract":"This study examined the role of lymphotoxin (LT)\u2010\u03b1<\/jats:italic> in host defense against airborne infection with Francisella tularensis<\/jats:italic>, a gram\u2010negative facultative intracellular bacterium and the causative agent of tularemia. Following a low\u2010dose aerosol infection with the highly virulent type A strain of F. tularensis<\/jats:italic>, mice deficient in LT\u03b1<\/jats:italic> (LT\u03b1<\/jats:italic>\u2212\/\u2212) consistently harbored approximately 10\u2010fold fewer bacteria in their spleens at day 2 and 10\u2010fold more bacteria in their lungs at day 4 than LT\u03b1<\/jats:italic>+\/+ mice. However, the mortality and median time to death were indistinguishable between the two mouse strains. In addition, the inflammatory responses to the infection, as reflected by the cytokine levels and leukocyte influx in the bronchoalveolar lavage fluid and histopathological analysis, were generally similar between LT\u03b1<\/jats:italic>\u2212\/\u2212 and LT\u03b1<\/jats:italic>+\/+ mice. These data suggest that although LT\u03b1<\/jats:italic> does not contribute significantly to the resistance and host responses of mice to airborne type A F. tularensis<\/jats:italic> infection, it does play a subtle role in the multiplication\/dissemination of F. tularensis<\/jats:italic>.<\/jats:p>","DOI":"10.1155\/2008\/239740","type":"journal-article","created":{"date-parts":[[2008,8,21]],"date-time":"2008-08-21T14:06:54Z","timestamp":1219327614000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Lymphotoxin\u2010\u03b1<\/i> Plays Only a Minor Role in Host Resistance to Respiratory Infection with Virulent Type A Francisella tularensis<\/i> in Mice"],"prefix":"10.1155","volume":"2008","author":[{"given":"Deng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhonda","family":"KuoLee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greg","family":"Harris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinxian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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