{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T01:18:15Z","timestamp":1784942295537,"version":"3.55.0"},"reference-count":23,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical and Developmental Immunology"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>We describe the effect on the neonate of administration of rituximab to a woman with idiopathic thrombocytopenic purpura (ITP). Rituximab, an anti-CD20 antibody, was given weekly for 4 weeks to a woman with ITP in her third trimester of pregnancy. One month after the last rituximab administration a healthy girl was born. She had normal growth and development during the first six months. At birth, B-lymphocytes were not detectable. Rituximab levels in mother and neonate were 24000 and 6700\u2009ng\/mL, respectively. Only 7 cases of rituximab administration during pregnancy were described. No adverse events are described for fetus and neonate. We demonstrate that rituximab passes the placenta and inhibits neonatal B-lymphocyte development. However, after 6 months B-lymphocyte levels normalized and vaccination titres after 10 months were adequate. No infection-related complications occurred. Rituximab administration during pregnancy appears to be safe for the child but further studies are warranted.<\/jats:p>","DOI":"10.1155\/2008\/271363","type":"journal-article","created":{"date-parts":[[2008,6,26]],"date-time":"2008-06-26T07:31:59Z","timestamp":1214465519000},"page":"1-6","source":"Crossref","is-referenced-by-count":158,"title":["Rituximab Administration in Third Trimester of Pregnancy Suppresses Neonatal B-Cell Development"],"prefix":"10.1155","volume":"2008","author":[{"given":"D. T.","family":"Klink","sequence":"first","affiliation":[{"name":"Department of Neonatology, VU University Medical Center, De Boelelaan 1117, 1018 HV Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. M.","family":"van Elburg","sequence":"additional","affiliation":[{"name":"Department of Neonatology, VU University Medical Center, De Boelelaan 1117, 1018 HV Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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