{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:55:50Z","timestamp":1792115750204,"version":"4.4.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,7,7]],"date-time":"2008-07-07T00:00:00Z","timestamp":1215388800000},"content-version":"vor","delay-in-days":188,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"crossref","award":["6834"],"award-info":[{"award-number":["6834"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Swedish Diabetes Foundation","award":["6834"],"award-info":[{"award-number":["6834"]}]},{"DOI":"10.13039\/501100006189","name":"Albert P\u00e5hlsson Foundation","doi-asserted-by":"crossref","award":["6834"],"award-info":[{"award-number":["6834"]}],"id":[{"id":"10.13039\/501100006189","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Swedish Diabetes Association","award":["6834"],"award-info":[{"award-number":["6834"]}]},{"DOI":"10.13039\/501100009780","name":"Region Sk\u00e5ne","doi-asserted-by":"crossref","award":["6834"],"award-info":[{"award-number":["6834"]}],"id":[{"id":"10.13039\/501100009780","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003252","name":"Lund University","doi-asserted-by":"crossref","award":["6834"],"award-info":[{"award-number":["6834"]}],"id":[{"id":"10.13039\/501100003252","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:p>Exogenous administration of islet amyloid polypeptide (IAPP) has been shown to inhibit both insulin and glucagon secretion. This study examined <jats:italic>\u03b1<\/jats:italic>\u2010cell function in mice with <jats:italic>\u03b2<\/jats:italic>\u2010cell specific overexpression of human IAPP (hIAPP) after an oral protein gavage (75\u2009mg whey protein\/mouse). Baseline glucagon levels were higher in transgenic mice (41\u00b14.0\u2009pg\/mL, <jats:italic>n<\/jats:italic> = 6) than in wildtype animals (19\u00b15.1\u2009pg\/mL, <jats:italic>n<\/jats:italic> = 5, <jats:italic>P<\/jats:italic> = .015). In contrast, the glucagon response to protein was impaired in transgenic animals (21\u00b12.7\u2009pg\/mL in transgenic mice versus 38\u00b15.7\u2009pg\/mL in wildtype mice at 15 minutes; <jats:italic>P<\/jats:italic> = .027). Baseline insulin levels did not differ between the groups, while the insulin response, as the glucagon response, was impaired after protein challenge (<jats:italic>P<\/jats:italic> = .018). Glucose levels were not different between the groups and did not change significantly after protein gavage. Acetaminophen was given through gavage to the animals (2\u2009mg\/mouse) to estimate gastric emptying. The plasma acetaminophen profile was similar in the two groups of mice. We conclude that disturbances in glucagon secretion exist in mice with <jats:italic>\u03b2<\/jats:italic>\u2010cell specific overexpression of human IAPP, which are not secondary to changes in gastric emptying. The reduced glucagon response to protein challenge may reflect a direct inhibitory influence of hIAPP on glucagon secretion.<\/jats:p>","DOI":"10.1155\/2008\/304513","type":"journal-article","created":{"date-parts":[[2008,7,9]],"date-time":"2008-07-09T07:39:14Z","timestamp":1215589154000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Disturbed \u03b1\u2010Cell Function in Mice with \u03b2\u2010Cell Specific Overexpression of Human Islet Amyloid Polypeptide"],"prefix":"10.1155","volume":"2008","author":[{"given":"Bo","family":"Ahr\u00e9n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"S\u00f6rhede Winzell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,7,7]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.11.3881"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02924339"},{"key":"e_1_2_6_3_2","first-page":"577","article-title":"IAPP as a regulator of glucose homeostasis and pancreatic hormone secretion (review)","volume":"3","author":"Karlsson E.","year":"1999","journal-title":"International Journal of Molecular Medicine"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-199508000-00015"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(91)90239-M"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-0115(93)90411-Z"},{"key":"e_1_2_6_7_2","first-page":"E300","article-title":"Islet amyloid polypeptide inhibits insulin secretion in conscious rats","volume":"267","author":"F\u00fcrnsinn C.","year":"1994","journal-title":"American Journal of Physiology"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(97)90170-0"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1999.276.1.E19"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-0115(02)00252-5"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2006.06.004"},{"key":"e_1_2_6_12_2","first-page":"522","article-title":"Islet amyloid polypeptide: mechanisms of amyloidogenesis in the pancreatic islets and potential roles in diabetes mellitus","volume":"66","author":"Johnson K. 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