{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:46:29Z","timestamp":1787496389807,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,8,4]],"date-time":"2008-08-04T00:00:00Z","timestamp":1217808000000},"content-version":"vor","delay-in-days":216,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 EB00975-01"],"award-info":[{"award-number":["R01 EB00975-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P41 RR15241-01A1"],"award-info":[{"award-number":["P41 RR15241-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P41 RR15241-02S1"],"award-info":[{"award-number":["P41 RR15241-02S1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50 MH071616"],"award-info":[{"award-number":["P50 MH071616"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01 AG026276"],"award-info":[{"award-number":["P01 AG026276"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 EB00975-01"],"award-info":[{"award-number":["R01 EB00975-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P41 RR15241-01A1"],"award-info":[{"award-number":["P41 RR15241-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P41 RR15241-02S1"],"award-info":[{"award-number":["P41 RR15241-02S1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50 MH071616"],"award-info":[{"award-number":["P50 MH071616"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01 AG026276"],"award-info":[{"award-number":["P01 AG026276"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 EB00975-01"],"award-info":[{"award-number":["R01 EB00975-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P41 RR15241-01A1"],"award-info":[{"award-number":["P41 RR15241-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P41 RR15241-02S1"],"award-info":[{"award-number":["P41 RR15241-02S1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50 MH071616"],"award-info":[{"award-number":["P50 MH071616"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01 AG026276"],"award-info":[{"award-number":["P01 AG026276"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 EB00975-01"],"award-info":[{"award-number":["R01 EB00975-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P41 RR15241-01A1"],"award-info":[{"award-number":["P41 RR15241-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P41 RR15241-02S1"],"award-info":[{"award-number":["P41 RR15241-02S1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50 MH071616"],"award-info":[{"award-number":["P50 MH071616"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01 AG026276"],"award-info":[{"award-number":["P01 AG026276"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 EB00975-01"],"award-info":[{"award-number":["R01 EB00975-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P41 RR15241-01A1"],"award-info":[{"award-number":["P41 RR15241-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P41 RR15241-02S1"],"award-info":[{"award-number":["P41 RR15241-02S1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50 MH071616"],"award-info":[{"award-number":["P50 MH071616"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01 AG026276"],"award-info":[{"award-number":["P01 AG026276"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:p>\n                    This paper describes the application of the alternating Kernel mixture (AKM) segmentation algorithm to high resolution MRI subvolumes acquired from a 1.5T scanner (hippocampus,\n                    <jats:italic>n<\/jats:italic>\n                    = 10 and prefrontal cortex,\n                    <jats:italic>n<\/jats:italic>\n                    = 9) and a 3T scanner (hippocampus,\n                    <jats:italic>n<\/jats:italic>\n                    = 10 and occipital lobe,\n                    <jats:italic>n<\/jats:italic>\n                    = 10). Segmentation of the subvolumes into cerebrospinal fluid, gray matter, and white matter tissue is validated by comparison with manual segmentation. When compared with other segmentation methods that use traditional Bayesian segmentation, AKM yields smaller errors (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; .005, exact Wilcoxon signed rank test) demonstrating the robustness and wide applicability of AKM across different structures. By generating multiple mixtures for each tissue compartment, AKM mimics the increased variation of manual segmentation in partial volumes due to the highly folded tissues. AKM\u2032s superior performance makes it useful for tissue segmentation of subcortical and cortical structures in large\u2010scale neuroimaging studies.\n                  <\/jats:p>","DOI":"10.1155\/2008\/346129","type":"journal-article","created":{"date-parts":[[2008,8,5]],"date-time":"2008-08-05T02:28:20Z","timestamp":1217903300000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Validation of Alternating Kernel Mixture Method: Application to Tissue Segmentation of Cortical and Subcortical Structures"],"prefix":"10.1155","volume":"2008","author":[{"given":"Nayoung A.","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carey E.","family":"Priebe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael I.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Tilak","family":"Ratnanather","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,8,4]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001580"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5306.1586"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2007.01.027"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.57.8.769"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/11.4.374"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1880020603"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.12.2000"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2006.08.006"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.12.051"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.202.2.9015081"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.05.005"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0906"},{"key":"e_1_2_7_13_2","first-page":"923","article-title":"Surface-based Gaussian random field model with  application to cortical thickness variation of left planum temporale in schizophrenia and bipolar disorder","volume":"29","author":"Qiu A.","year":"2008","journal-title":"Human Brain Mapping"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.05.007"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2007.02.021"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2136624100"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1109\/42.906426"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1999.0428"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2000.0666"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1109\/42.511747"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1287"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1361-8415(03)00037-9"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2000.0649"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2000.0730"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.csda.2004.09.003"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-9473(00)00003-7"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1013203454"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2004.07.003"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20331"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.11.049"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2006.05.006"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0895-6111(89)90285-1"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00569-X"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0831"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00238-6"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/0471200611"},{"key":"e_1_2_7_37_2","doi-asserted-by":"crossref","unstructured":"GerigG. JomierM. andChakosM. Valmet: a new validation tool for assessing and improving 3D object segmentation 2208 Proceedings of the 4th International Conference on Medical Image Computing and Computer-Assisted Intervention (MICCAI \u203201) October 2001 Utrecht The Netherlands 516\u2013523 Lecture Notes in Computer Science.","DOI":"10.1007\/3-540-45468-3_62"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1109\/42.363096"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.11.031"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2008\/346129.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2008\/346129.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2008\/346129","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T16:22:49Z","timestamp":1719505369000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2008\/346129"}},"subtitle":[],"editor":[{"given":"Daniel","family":"Howard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["10.1155\/2008\/346129"],"URL":"https:\/\/doi.org\/10.1155\/2008\/346129","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1]]},"assertion":[{"value":"2007-09-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-06-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-08-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"346129"}}