{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T19:01:07Z","timestamp":1793473267197,"version":"4.5.0"},"reference-count":0,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Scientific Research Fund of Guangdong","award":["2005B30601019"],"award-info":[{"award-number":["2005B30601019"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:p><jats:italic>Objective:<\/jats:italic> Oxidized LDL cholesterol (ox\u2010LDL\u2010C) is considered to be a key factor of initiating and accelerating atherosclerosis (AS). The purpose of this study is to elucidate the sensitivity and specificity of ox\u2010LDL and oxidation ratio of LDL in the diagnosis of coronary artery disease (CAD). For the first time, we investigated the ratio of ox\u2010LDL to ALB(ox\u2010LDL\/ALB).<\/jats:p><jats:p><jats:italic>Methods and results:<\/jats:italic> Blood ox\u2010LDL, total cholesterol (TC), high density lipoprotein cholesterol (HDL\u2010C), low density lipoprotein cholesterol (LDL\u2010C), triglyceride (TG) and albumin (ALB) were measured in patients with acute myocardial infarction (AMI, <jats:italic>n<\/jats:italic> = 80), unstable angina pectoris (UAP, <jats:italic>n<\/jats:italic> = 80), stable angina pectoris (SAP, <jats:italic>n<\/jats:italic> = 80), normal control (<jats:italic>n<\/jats:italic> = 60), and dyslipidemia control (<jats:italic>n<\/jats:italic> = 60). Ox\u2010LDL was measured by competitive ELISA. The level of ox\u2010LDL and oxidation ratio of LDL(ox\u2010LDL\/TC, ox\u2010LDL\/HDL\u2010C, ox\u2010LDL\/ LDL\u2010C and ox\u2010LDL\/ALB) were significantly higher in each diseased group than controls (<jats:italic>P<\/jats:italic> &lt; 0.001). In CAD group, ox\u2010LDL and oxidation ratio of LDL in subjects complicated with hypertension (HT) and\/or diabetes mellitus (DM) increased further (<jats:italic>P<\/jats:italic> &lt; 0.001). Ox\u2010LDL\/ALB in the AMI group was 7 times higher than normal control group (0.068 \u00b1 0.017 vs 0.009 \u00b1 0.007, <jats:italic>P<\/jats:italic> &lt; 0.001). The area under the curve (AUC) of receiver operating characteristic curve (ROC curve) is a criterium to evaluate the accuracy of diagnosing a disease. The AUC of ROC curve of ox\u2010LDL\/TC, ox\u2010LDL\/HDL\u2010C, ox\u2010LDL, ox\u2010LDL\/ALB and ox\u2010LDL\/ LDL\u2010C for diagnosing CAD were 0.975, 0.975, 0.966, 0.966, 0.957 respectively (<jats:italic>P<\/jats:italic> &lt; 0.001). When ox\u2010LDL\/TC = 0.175, the sensitivity and specificity of diagnosing CAD were 0.917 and 0.925, which were almost equal to each other, indicating that the rates of missed diagnosis and misdiagnosis for CAD were the lowest.<\/jats:p><jats:p><jats:italic>Conclusions:<\/jats:italic> The level of ox\u2010LDL and the ratio of ox\u2010LDL\/TC, ox\u2010LDL\/LDL\u2010C, ox\u2010LDL\/HDL\u2010C and ox\u2010LDL\/ALB are better biomarkers than TC, TG, HDL\u2010C and LDL\u2010C for discriminating between patients with coronary artery disease and healthy subjects. And patients who have a high ratio of ox\u2010LDL \/TC may have a higher risk for CAD.<\/jats:p>","DOI":"10.1155\/2008\/371314","type":"journal-article","created":{"date-parts":[[2013,6,13]],"date-time":"2013-06-13T11:36:39Z","timestamp":1371123399000},"page":"341-349","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["The oxidation ratio of LDL: A Predictor for Coronary Artery Disease"],"prefix":"10.1155","volume":"24","author":[{"given":"Huiling","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyi","family":"Mai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuantao","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yugang","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,7,23]]},"container-title":["Disease Markers"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2008\/371314.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2008\/371314","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T09:56:42Z","timestamp":1723111002000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2008\/371314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["10.1155\/2008\/371314"],"URL":"https:\/\/doi.org\/10.1155\/2008\/371314","archive":["Portico"],"relation":{},"ISSN":["0278-0240","1875-8630"],"issn-type":[{"value":"0278-0240","type":"print"},{"value":"1875-8630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1]]},"assertion":[{"value":"2008-07-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}