{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T08:09:42Z","timestamp":1769242182114,"version":"3.49.0"},"reference-count":0,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Respiratory Journal"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:p>BACKGROUND: Occupational exposures are an important cause of adult\u2010onset asthma but the population attributable risk percentage (PAR%) has been less frequently studied.<\/jats:p><jats:p>OBJECTIVES: To examine the distribution and determinants of adult asthma in six centres across Canada using data gathered in a community\u2010based study.<\/jats:p><jats:p>METHODS: Data were gathered in a community survey of 2959 adults using the European Community Respiratory Health Survey Protocol. A subsample of 498 subjects completed detailed health and occupational questionnaires, methacholine challenge tests and allergy skin tests. Asthma was defined in three ways: current wheeze, asthma symptoms and\/or medication, and airway hyperresponsiveness. Occupational exposures were classified as sensitizers or irritants. Associations between asthma and occupational exposures were examined using logistic regression analysis. Model selection was based on the findings for current wheeze, and the same model was applied to the other definitions of asthma.<\/jats:p><jats:p>RESULTS: Fifty\u2010six per cent of subjects reported ever having had occupational exposure to sensitizers, and 9.8% to irritants. Current wheeze was associated with exposure to irritants (PAR% 4.54%), and airway hyperresponsiveness was associated with exposure to sensitizers (PAR% 30.7%). Neither a history of childhood asthma, atopy, nor confining the analysis to adult\u2010onset asthma affected these associations. Analysis of effect modification suggested two types of work\u2010related asthma: one due to exposure to occupational sensitizers, and the other due to exposure to irritants.<\/jats:p><jats:p>CONCLUSIONS: Detailed assessment of past and current exposures is essential in the investigation of work\u2010related asthma. Childhood asthma reactivated or aggravated by work exposures is not easy to distinguish from asthma induced by work, a misclassification that could lead to an underestimation of work\u2010induced asthma. This should be taken into account in jurisdictions in which persons with work\u2010aggravated asthma are not eligible for workers\u2019 compensation.<\/jats:p>","DOI":"10.1155\/2008\/391269","type":"journal-article","created":{"date-parts":[[2016,3,15]],"date-time":"2016-03-15T07:55:31Z","timestamp":1458028531000},"page":"406-412","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Work\u2010Related Asthma in Montreal, Quebec: Population Attributable Risk in a Community\u2010Based Study"],"prefix":"10.1155","volume":"15","author":[{"given":"Ahmet","family":"Demir","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence","family":"Joseph","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret R","family":"Becklake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,1]]},"container-title":["Canadian Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crj\/2008\/391269.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2008\/391269","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T18:58:20Z","timestamp":1722365900000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2008\/391269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["10.1155\/2008\/391269"],"URL":"https:\/\/doi.org\/10.1155\/2008\/391269","archive":["Portico"],"relation":{},"ISSN":["1198-2241","1916-7245"],"issn-type":[{"value":"1198-2241","type":"print"},{"value":"1916-7245","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1]]},"assertion":[{"value":"2008-01-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}