{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:36:58Z","timestamp":1791229018191,"version":"4.1.0"},"reference-count":80,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,5,6]],"date-time":"2008-05-06T00:00:00Z","timestamp":1210032000000},"content-version":"vor","delay-in-days":126,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003092","name":"Dutch Diabetes Research Foundation","doi-asserted-by":"crossref","award":["2002.00.019"],"award-info":[{"award-number":["2002.00.019"]}],"id":[{"id":"10.13039\/501100003092","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["2002.00.019"],"award-info":[{"award-number":["2002.00.019"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:p>The presence of fibrillar protein deposits (amyloid) of human islet amyloid polypeptide (hIAPP) in the pancreatic islets of Langerhans is thought to be related to death of the insulin\u2010producing islet <jats:italic>\u03b2<\/jats:italic>\u2010cells in type 2 diabetes mellitus (DM2). The mechanism of hIAPP\u2010induced <jats:italic>\u03b2<\/jats:italic>\u2010cell death is not understood. However, there is growing evidence that hIAPP\u2010induced disruption of <jats:italic>\u03b2<\/jats:italic>\u2010cell membranes is the cause of hIAPP cytotoxicity. Amyloid cytotoxicity by membrane damage has not only been suggested for hIAPP, but also for peptides and proteins related to other misfolding diseases, like Alzheimer_s disease, Parkinson\u2032s disease, and prion diseases. Here we review the interaction of hIAPP with membranes, and discuss recent progress in the field, with a focus on hIAPP structure and on the proposed mechanisms of hIAPP\u2010induced membrane damage in relation to <jats:italic>\u03b2<\/jats:italic>\u2010cell death in DM2.<\/jats:p>","DOI":"10.1155\/2008\/421287","type":"journal-article","created":{"date-parts":[[2008,5,8]],"date-time":"2008-05-08T15:55:25Z","timestamp":1210262125000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":109,"title":["Recent Insights in Islet Amyloid Polypeptide\u2010Induced Membrane Disruption and Its Role in \u03b2\u2010Cell Death  in Type 2  Diabetes Mellitus"],"prefix":"10.1155","volume":"2008","author":[{"given":"Lucie","family":"Khemt\u00e9mourian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Antoinette Killian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo W. M.","family":"H\u00f6ppener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten F. M.","family":"Engel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,3,18]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00549079"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.11.3881"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.23.8628"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)90825-7"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/368756a0"},{"key":"e_1_2_8_6_2","first-page":"609","article-title":"Human islet amyloid polypeptide expression in COS-1 cells. A model of intracellular amyloidogenesis","volume":"147","author":"O\u2032Brien T. D.","year":"1995","journal-title":"American Journal of Pathology"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.3.491"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65360-6"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1006\/cbir.2000.0643"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(89)81467-X"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051175"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.13.5036"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00044a038"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.1998.2510208.x"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1999.2646"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2001.4593"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2001.4608"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi0160462"},{"key":"e_1_2_8_19_2","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1110\/ps.9.2.427","article-title":"Direct measurement of islet amyloid polypeptide fibrillogenesis by mass spectrometry","volume":"9","author":"Larson J. L.","year":"2000","journal-title":"Protein Science"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1110\/ps.041051205"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1110\/ps.062486907"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0703306104"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.66.1.385"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(89)90046-8"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4838(92)90411-6"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1006\/jsbi.2000.4268"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi050840w"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi060579z"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi020314u"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M312452200"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C400260200"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi001315u"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000192103.24796.42"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1079469"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1006\/jsbi.1997.3858"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2003.11.048"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M406853200"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05695"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi981658g"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3765(20020916)8:18<4285::AID-CHEM4285>3.0.CO;2-0"},{"key":"e_1_2_8_41_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi048582a"},{"key":"e_1_2_8_42_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0507471103"},{"key":"e_1_2_8_43_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja072157y"},{"key":"e_1_2_8_44_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M102883200"},{"key":"e_1_2_8_45_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi0621967"},{"key":"e_1_2_8_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(02)00887-2"},{"key":"e_1_2_8_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1047-8477(02)00630-5"},{"key":"e_1_2_8_48_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi051432v"},{"key":"e_1_2_8_49_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-003-1304-4"},{"key":"e_1_2_8_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2004.06.086"},{"key":"e_1_2_8_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2004.09.075"},{"key":"e_1_2_8_52_2","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.107.110635"},{"key":"e_1_2_8_53_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0502066102"},{"key":"e_1_2_8_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2005.12.020"},{"key":"e_1_2_8_55_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.22.10573"},{"key":"e_1_2_8_56_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1994.tb44414.x"},{"key":"e_1_2_8_57_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.4.1988"},{"key":"e_1_2_8_58_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2006.05367.x"},{"key":"e_1_2_8_59_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M500997200"},{"key":"e_1_2_8_60_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi034889i"},{"key":"e_1_2_8_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2004.12.085"},{"key":"e_1_2_8_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(01)02972-6"},{"key":"e_1_2_8_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2004.07.052"},{"key":"e_1_2_8_64_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00082.2006"},{"key":"e_1_2_8_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/416507a"},{"key":"e_1_2_8_66_2","doi-asserted-by":"publisher","DOI":"10.1385\/CBB:36:2-3:191"},{"key":"e_1_2_8_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2007.07.001"},{"key":"e_1_2_8_68_2","doi-asserted-by":"publisher","DOI":"10.2337\/db07-0197"},{"key":"e_1_2_8_69_2","doi-asserted-by":"publisher","DOI":"10.2337\/db06-1579"},{"key":"e_1_2_8_70_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.10.1962"},{"key":"e_1_2_8_71_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0708354105"},{"key":"e_1_2_8_72_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2381-04.2005"},{"key":"e_1_2_8_73_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi048510j"},{"key":"e_1_2_8_74_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi049002c"},{"key":"e_1_2_8_75_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0407035102"},{"key":"e_1_2_8_76_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200602034"},{"key":"e_1_2_8_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(95)01512-4"},{"key":"e_1_2_8_78_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20030852"},{"key":"e_1_2_8_79_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02538912"},{"key":"e_1_2_8_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2007.03.030"}],"container-title":["Journal of Diabetes Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jdr\/2008\/421287.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jdr\/2008\/421287.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2008\/421287","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T13:23:08Z","timestamp":1719580988000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2008\/421287"}},"subtitle":[],"editor":[{"given":"Per","family":"Westermark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":80,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["10.1155\/2008\/421287"],"URL":"https:\/\/doi.org\/10.1155\/2008\/421287","archive":["Portico"],"relation":{},"ISSN":["2314-6745","2314-6753"],"issn-type":[{"value":"2314-6745","type":"print"},{"value":"2314-6753","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1]]},"assertion":[{"value":"2007-10-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-02-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-03-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"421287"}}