{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:27:09Z","timestamp":1791404829109,"version":"4.3.3"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,9,24]],"date-time":"2008-09-24T00:00:00Z","timestamp":1222214400000},"content-version":"vor","delay-in-days":267,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Swedish Diabetes Association"},{"DOI":"10.13039\/501100006415","name":"Family Ernfors Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006415","id-type":"DOI","asserted-by":"crossref"}]},{"name":"European Union FP6 Program"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:p>Transthyretin (TTR) is a major amyloid fibril protein in certain systemic forms of amyloidosis. It is a plasma protein, mainly synthesized by the liver but expression occurs also at certain minor locations, including the endocrine cells in the islets of Langerhans. With the use of immunohistochemistry and in situ hybridization, we have studied the distribution of transthyretin\u2010containing cells in islets of Langerhans in type\u20102 diabetic and nondiabetic individuals. TTR expression was particularly seen in alpha (glucagon) cells. Islets from type\u20102 diabetic patients had proportionally more transthyretin\u2010reactive islet cells, including beta cells. A weak transthyretin immunoreaction in IAPP\u2010derived amyloid occurred in some specimens. In seeding experiments in vitro, we found that TTR fibrils did not seed IAPP while IAPP fibrils seeded TTR. It is suggested that islet expression of transthyretin may be altered in type\u20102 diabetes.<\/jats:p>","DOI":"10.1155\/2008\/429274","type":"journal-article","created":{"date-parts":[[2008,9,25]],"date-time":"2008-09-25T13:04:33Z","timestamp":1222347873000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Transthyretin and Amyloid in the Islets of Langerhans in Type\u20102 Diabetes"],"prefix":"10.1155","volume":"2008","author":[{"given":"Gunilla T.","family":"Westermark","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Westermark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,9,24]]},"reference":[{"key":"e_1_2_6_1_2","first-page":"189","volume-title":"Diabetes: Clinical Science in Practice","author":"Westermark P.","year":"1995"},{"key":"e_1_2_6_2_2","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1699-0463.1973.tb03538.x","article-title":"The pancreatic islet cells in insular amyloidosis in human diabetic and non diabetic adults","volume":"81","author":"Westermark P.","year":"1973","journal-title":"Acta Pathologica et Microbiologica Scandinavica A"},{"key":"e_1_2_6_3_2","first-page":"151","article-title":"Islet amyloid, increased A-cells, reduced B-cells and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes","volume":"9","author":"Clark A.","year":"1988","journal-title":"Diabetes Research"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(95)01512-4"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.7014"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3310809"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00500385"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.8.3492"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051175"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03402051"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/13506120701460923"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90635-4"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-440X(99)00049-4"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2003.12.008"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1110\/ps.04707004"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M311300200"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.5.2558"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3780257"},{"key":"e_1_2_6_19_2","article-title":"Prealbumin in the islets of Langerhans","volume":"7","author":"Jacobsson B.","year":"1979","journal-title":"IRCS Medical Science"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-003-1300-8"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.3109\/13506120308998998"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(82)90040-X"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)39583-2"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.8.2488"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00493004"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1177\/10.3.355"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00399947"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.5260"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00400235"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00285291"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00274799"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001250050751"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1177\/37.1.2642294"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi049621l"},{"key":"e_1_2_6_35_2","first-page":"238","article-title":"Conformational mimicry in Alzheimer\u2032s disease: role of apolipoproteins in amyloidogenesis","volume":"147","author":"Wisniewski T.","year":"1995","journal-title":"American Journal of Pathology"}],"container-title":["Journal of Diabetes Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jdr\/2008\/429274.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jdr\/2008\/429274.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2008\/429274","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T13:23:30Z","timestamp":1719581010000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2008\/429274"}},"subtitle":[],"editor":[{"given":"Steven E.","family":"Kahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["10.1155\/2008\/429274"],"URL":"https:\/\/doi.org\/10.1155\/2008\/429274","archive":["Portico"],"relation":{},"ISSN":["2314-6745","2314-6753"],"issn-type":[{"value":"2314-6745","type":"print"},{"value":"2314-6753","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1]]},"assertion":[{"value":"2008-01-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-07-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-09-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"429274"}}