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We investigated the regulation of HMGB\u20101 in human peripheral blood mononuclear cells (PBMCs) following stimulation with the staphylococcal superantigen, toxic shock syndrome toxin\u20101 (TSST\u20101), and found that TSST\u20101, like LPS, induced the secretion of HMGB\u20101 from human PBMC. However, unlike monocyte\u2010driven sepsis caused by endotoxin, translocation and secretion of HMGB\u20101 mediated by TSST\u20101 was dependent on the presence of both activated T cells and monocytes. Furthermore, we show that nuclear HMGB\u20101 is released from TSST\u20101 stimulated T cells. This finding presents a basis for investigating the potential of targeting HMGB\u20101 for the treatment of toxic shock syndrome, and provides further insight on the role of HMGB\u20101 in the cross\u2010talk between activated monocytes and T cells.<\/jats:p>","DOI":"10.1155\/2008\/512196","type":"journal-article","created":{"date-parts":[[2008,11,5]],"date-time":"2008-11-05T06:46:49Z","timestamp":1225867609000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Staphylococcal Toxic Shock Syndrome Toxin\u20101 Induces  the Translocation and Secretion of High Mobility Group\u20101 Protein from Both Activated T Cells and Monocytes"],"prefix":"10.1155","volume":"2008","author":[{"given":"Shirin","family":"Kalyan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony 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