{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T11:43:46Z","timestamp":1774525426823,"version":"3.50.1"},"reference-count":0,"publisher":"Hindawi Limited","issue":"3","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Gastroenterology"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>BACKGROUND: Infection with different genotypes of virulent<jats:italic>Helicobacter pylori<\/jats:italic>strains (cytotoxin-associated gene A [CagA]-and\/or vacuolating cytotoxin A [VacA]-positive) can play a role in the development of atrophic gastritis, duodenal ulcer (DU) and gastric cancer (GC).<\/jats:p><jats:p>OBJECTIVE: To determine whether patients with GC and<jats:italic>H pylori<\/jats:italic>-negative histological staining had previously been infected with<jats:italic>H pylori<\/jats:italic>CagA- and\/or VacA-positive virulent strains.<\/jats:p><jats:p>METHODS: Twenty-three GC patients with a mean (\u00b1 SD) age of 68.14\u00b19.8 years who tested<jats:italic>H pylori<\/jats:italic>-negative on histological staining took part in the study. Three control groups were included. The first group comprised 19 patients with past<jats:italic>H pylori<\/jats:italic>infection and DUs eradicated 10 years earlier, with a mean age of 58\u00b118.2 years.<jats:italic>H pylori<\/jats:italic>-negative status for this group was determined every year with Giemsa staining, and follow-up testing occured 120\u00b132 months (mean \u00b1 SD) after therapy. The subsequent control groups included 20 asymptomatic children, with a mean age of 7\u00b14.47 years, and with<jats:italic>H pylori<\/jats:italic>-negative fecal tests; the final group contained 30 patients without clinical symptoms of<jats:italic>H pylori<\/jats:italic>infection, with a mean age of 68\u00b111.6 years, who tested<jats:italic>H pylori<\/jats:italic>-negative by histological staining.<\/jats:p><jats:p>RESULTS: Prevalence of CagA and VacA seropositivity, respectively was 82.6% and 73.91% in GC patients; 84.2% and 84.2% in<jats:italic>H pylori<\/jats:italic>-negative DU patients; 25% and 5% in<jats:italic>H pylori<\/jats:italic>-negative children; and 36.6% and 16.6% in the patients without clinical symptoms on histological staining. CagA and VacA antibody positivity was not significantly different between GC patients and patients with DUs that had been eradicated 10 years earlier. Significant positivity was found between the children\u2019s group and the<jats:italic>H pylori<\/jats:italic>-negative (with past DUs) group (P&lt;0.001). A statistically significant difference was found in age between groups (P&lt;0.03).<\/jats:p><jats:p>CONCLUSIONS: Patients with GC, even when<jats:italic>H pylori<\/jats:italic>-negative at the time of the present study, may have been infected by<jats:italic>H pylori<\/jats:italic>before the onset of the disease, as confirmed by CagA and VacA seropositivity. These data reinforce the hypothesis that<jats:italic>H pylori<\/jats:italic>may be a direct carcinogenic agent of GC.<\/jats:p>","DOI":"10.1155\/2008\/521724","type":"journal-article","created":{"date-parts":[[2016,3,15]],"date-time":"2016-03-15T07:58:34Z","timestamp":1458028714000},"page":"255-258","source":"Crossref","is-referenced-by-count":24,"title":["CagA and VacA<i>Helicobacter Pylori<\/i>Antibodies in Gastric Cancer"],"prefix":"10.1155","volume":"22","author":[{"given":"Renzo","family":"Suriani","sequence":"first","affiliation":[{"name":"Gastroenterology Clinical Unit, Gastroenterologia ed Endoscopia Digestiva, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurilio","family":"Colozza","sequence":"additional","affiliation":[{"name":"Laboratorio analisi, Ospedale Nuovo, Rivoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Cardesi","sequence":"additional","affiliation":[{"name":"Dipartimento di Anatomia Patologica, Ospedale Martini, Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Mazzucco","sequence":"additional","affiliation":[{"name":"Gastroenterology Clinical Unit, Gastroenterologia ed Endoscopia Digestiva, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Marino","sequence":"additional","affiliation":[{"name":"Medicina Interna II, Universit\u00e0 di Modena e Reggio Emilia, Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Grosso","sequence":"additional","affiliation":[{"name":"Gastroenterology Clinical Unit, Gastroenterologia ed Endoscopia Digestiva, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabina","family":"Sanseverinati","sequence":"additional","affiliation":[{"name":"Medicina Interna II, Universit\u00e0 di Modena e Reggio Emilia, Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivo","family":"Venturini","sequence":"additional","affiliation":[{"name":"Medicina Interna II, Universit\u00e0 di Modena e Reggio Emilia, Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athos","family":"Borghi","sequence":"additional","affiliation":[{"name":"Medicina Interna II, Universit\u00e0 di Modena e Reggio Emilia, Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Luisa","family":"Zeneroli","sequence":"additional","affiliation":[{"name":"Medicina Interna II, Universit\u00e0 di Modena e Reggio Emilia, Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","container-title":["Canadian Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2008\/521724.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2008\/521724.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T12:14:02Z","timestamp":1471954442000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/cjgh\/2008\/521724\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008]]}},"alternative-id":["521724"],"URL":"https:\/\/doi.org\/10.1155\/2008\/521724","relation":{},"ISSN":["0835-7900"],"issn-type":[{"value":"0835-7900","type":"print"}],"subject":[],"published":{"date-parts":[[2008]]}}}