{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:45:05Z","timestamp":1791423905933,"version":"4.3.3"},"reference-count":21,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infectious Diseases in Obstetrics and Gynecology"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p><jats:italic>Objectives<\/jats:italic>. The ability of a probiotic<jats:italic>Lactobacillus rhamnosus<\/jats:italic>strain (Lcr35) to adhere to cervical and vaginal cells and to affect the viability of two main vaginosis-associated pathogens,<jats:italic>Prevotella bivia, Gardnerella vaginalis<\/jats:italic>, as well as<jats:italic>Candida albicans<\/jats:italic>was investigated.<jats:italic>Methods<\/jats:italic>. Adhesion ability was determined in vitro with immortalized epithelial cells from the endocervix, ectocervix, and vagina. Coculture experiments were performed to count viable pathogens cells in the presence of Lcr35.<jats:italic>Results<\/jats:italic>. Lcr35 was able to specifically and rapidly adhere to the three cell lines. In coculture assays, a decrease in pathogen cell division rate was observed as from 4 hours of incubation and bactericidal activity after a longer period of incubation, mostly with<jats:italic>P. bivia<\/jats:italic>.<jats:italic>Conclusion<\/jats:italic>. The ability of Lcr35 to adhere to cervicovaginal cells and its antagonist activities against vaginosis-associated pathogens suggest that this probiotic strain is a promising candidate for use in therapy.<\/jats:p>","DOI":"10.1155\/2008\/549640","type":"journal-article","created":{"date-parts":[[2009,1,27]],"date-time":"2009-01-27T15:25:32Z","timestamp":1233069932000},"page":"1-5","source":"Crossref","is-referenced-by-count":69,"title":["Adhesion of Human Probiotic<i>Lactobacillus rhamnosus<\/i>to Cervical and Vaginal Cells and Interaction with Vaginosis-Associated Pathogens"],"prefix":"10.1155","volume":"2008","author":[{"given":"Sophie","family":"Coudeyras","sequence":"first","affiliation":[{"name":"Laboratory of Bacteriology, UFR Pharmacy, University Clermont 1, 28 place H. 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