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After that, more pessimistic views spread when long\u2010term results of the clinical outcome were published. A progressive loss of the <jats:italic>\u03b2<\/jats:italic>\u2010cell function meant that almost all patients were back on insulin therapy after 5 years. More than 10 years ago, we demonstrated that amyloid deposits rapidly formed in human islets and in mouse islets transgenic for human IAPP when grafted into nude mice. It is, therefore, conceivable to consider amyloid formation as one potential candidate for the long\u2010term failure. The present paper reviews attempts in our laboratories to elucidate the dynamics of and mechanisms behind the formation of amyloid in transplanted islets with special emphasis on the impact of long\u2010term hyperglycemia.<\/jats:p>","DOI":"10.1155\/2008\/562985","type":"journal-article","created":{"date-parts":[[2009,3,8]],"date-time":"2009-03-08T13:59:19Z","timestamp":1236520759000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Amyloid Deposition in Transplanted Human Pancreatic Islets: A Conceivable Cause of Their Long\u2010Term Failure"],"prefix":"10.1155","volume":"2008","author":[{"given":"Arne","family":"Andersson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Bohman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. A. 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