{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:30:45Z","timestamp":1792521045824,"version":"4.5.0"},"reference-count":55,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical and Developmental Immunology"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. Limited information exists on features of pediatric Selective IgM immunodeficiency (SIgMID). Previously published pediatric cases and 2 new cases are reviewed.<jats:italic>Methods<\/jats:italic>. English literature from PubMed and references from relevant articles were reviewed. Previously reported cases and 2 new cases from an allergy\/immunology practice were analyzed.<jats:italic>Results<\/jats:italic>. Forty-nine reported cases of SIgMID presented with respiratory infections (77.6%), gastrointestinal disease (16.3%), skin disease (12.2%), and meningitis (8.2%). Mean serum IgM level was \u2009mg\/dL. Two patients were identified with SIgMID among 6300 active pediatric patients (0.03%) presenting with asthma, vasomotor rhinitis, and recurrent respiratory infections. In the 51 cases reported, none developed lymphoproliferative disease nor evolved into panhypogammaglobulinemia; four fatalities were reported.<jats:italic>Conclusions<\/jats:italic>. The prevalence of SIgMID in our pediatric population was 0.03%. In general, respiratory infections are the common comorbid conditions. Death and autoimmune disease are uncommon complications of pediatric SIgMID.<\/jats:p>","DOI":"10.1155\/2008\/624850","type":"journal-article","created":{"date-parts":[[2008,11,25]],"date-time":"2008-11-25T14:54:18Z","timestamp":1227624858000},"page":"1-10","source":"Crossref","is-referenced-by-count":35,"title":["Pediatric Selective IgM Immunodeficiency"],"prefix":"10.1155","volume":"2008","author":[{"given":"Marc F.","family":"Goldstein","sequence":"first","affiliation":[{"name":"The Asthma Center, Allergic Disease Associates, PC, 205 N. 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