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This could lead to disproportionately large blood oxygenation level\u2010dependent (BOLD) signal increases for a given flow increase during monocular (relative to binocular) stimulation, due to contributions from columns which undergo large increases in perfusion with little or no change in oxidative metabolism.  In the present study, we sought to test this hypothesis by measuring BOLD\u2010perfusion coupling ratios in spatially averaged signals over V1 during monocular and binocular visual stimulation. It was found that, although withholding input to one eye resulted in statistically significant decreases in BOLD and perfusion signals in primary visual cortex, the ratio between BOLD and perfusion increases did not change significantly. These results do not support a gross mismatch between spatial patterns of flow and metabolism response during monocular stimulation.<\/jats:p>","DOI":"10.1155\/2008\/628718","type":"journal-article","created":{"date-parts":[[2008,3,9]],"date-time":"2008-03-09T08:11:17Z","timestamp":1205050277000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["BOLD\u2010Perfusion Coupling during Monocular and  Binocular Stimulation"],"prefix":"10.1155","volume":"2008","author":[{"given":"Claudine","family":"Gauthier","sequence":"first","affiliation":[]},{"given":"Richard D.","family":"Hoge","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2008,3,2]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21171"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.10.044"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600186"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.05.013"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00477-9"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.191101098"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/375780a0"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.26.14826"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.272.5261.551"},{"key":"e_1_2_7_10_2","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1523\/JNEUROSCI.08-05-01500.1988","article-title":"Functional anatomy of macaque striate cortex. 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