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In the cornea of diabetic GK rats, more long\u2010spacing collagen fibrils were observed in Descemet\u2032s membrane than in the membrane of the nondiabetic Wistar rats. Both GK and Wistar rats showed an age\u2010dependent increase in the density of the long\u2010spacing collagen. Immunoelectron microscopy showed that type VIII collagen was localized in the internodal region of the long\u2010spacing collagen, which was not labelled by any of the other antibodies used. The antidiabetic agents nateglinide and glibenclamide significantly suppressed the formation of the long\u2010spacing collagen in the diabetic rats. Long\u2010spacing collagen would thus be a useful indicator for studying diabetic changes in the cornea and the effect of antidiabetic agents.<\/jats:p>","DOI":"10.1155\/2008\/818341","type":"journal-article","created":{"date-parts":[[2008,9,4]],"date-time":"2008-09-04T13:06:18Z","timestamp":1220533578000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Change in Long\u2010Spacing Collagen in                          Descemet\u2032s Membrane of Diabetic Goto\u2010Kakizaki Rats                          and Its Suppression by Antidiabetic Agents"],"prefix":"10.1155","volume":"2008","author":[{"given":"Yoshihiro","family":"Akimoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Sawada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mica","family":"Ohara-Imaizumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Nagamatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayato","family":"Kawakami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,9,2]]},"reference":[{"key":"e_1_2_6_1_2","first-page":"548","article-title":"Corneal epithelial basement membrane changes in diabetes","volume":"20","author":"Taylor H. 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