{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T05:04:09Z","timestamp":1648875849385},"reference-count":9,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Medicine"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>We report the clinical course of two siblings with Werner's syndrome (WS) who were diagnosed and followed at our clinics for 12 years. Initial diagnosis of the first sibling (sister) was at age 20, the second (brother) at 16. At the initial diagnosis, the sister had amenorrhea, muscle atrophy at arms and legs, diabetes mellitus (DM), short stature, bilateral cataracts, genital hypoplasia, osteoporosis, and gray hair. During 12 years follow-up period, high-pitched voice, hepatosteatosis, renal parenchymal disease, and urethral obstruction developed. Regarding the brother, DM, cataracts and genital hypoplasia were observed at the initial diagnosis. During the 12 years follow-up period, gray hair, high-pitched voice, steatohepatosis, and osteoporosis developed.<\/jats:p>","DOI":"10.1155\/2009\/138312","type":"journal-article","created":{"date-parts":[[2010,2,7]],"date-time":"2010-02-07T10:30:25Z","timestamp":1265538625000},"page":"1-3","source":"Crossref","is-referenced-by-count":1,"title":["Review of Two Siblings with Werner's Syndrome: A Case Report"],"prefix":"10.1155","volume":"2009","author":[{"given":"Murat","family":"Sert","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Department of Internal Medicine, Medical Faculty, Cukurova University, 01330 Adana, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koray","family":"Fakioglu","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Internal Medicine, Medical Faculty, Cukurova University, 01330 Adana, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamer","family":"Tetiker","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Internal Medicine, Medical Faculty, Cukurova University, 01330 Adana, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"2","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1097\/00000441-194111000-00002","volume":"202","year":"1941","journal-title":"The American Journal of the Medical Sciences"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1269\/jrr.07017"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2007.02641.x"},{"issue":"3","key":"4","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1172\/JCI109511","volume":"64","year":"1979","journal-title":"Journal of Clinical Investigation"},{"issue":"3","key":"5","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/jcp.1040920305","volume":"92","year":"1977","journal-title":"Journal of Cellular Physiology"},{"issue":"1","key":"6","first-page":"86","volume":"23","year":"1970","journal-title":"Laboratory Investigation"},{"key":"7","first-page":"1215","volume":"16","year":"1979","journal-title":"Taisya"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2004.03.009"},{"issue":"6","key":"10","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/BF00350541","volume":"16","year":"1987","journal-title":"Skeletal Radiology"}],"container-title":["Case Reports in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crim\/2009\/138312.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crim\/2009\/138312.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crim\/2009\/138312.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T00:34:01Z","timestamp":1497832441000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/crim\/2009\/138312\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":9,"alternative-id":["138312","138312"],"URL":"https:\/\/doi.org\/10.1155\/2009\/138312","relation":{},"ISSN":["1687-9627","1687-9635"],"issn-type":[{"value":"1687-9627","type":"print"},{"value":"1687-9635","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}