{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T23:53:14Z","timestamp":1778889194670,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2009,9,24]],"date-time":"2009-09-24T00:00:00Z","timestamp":1253750400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advances in Bioinformatics"],"published-print":{"date-parts":[[2009,9,24]]},"abstract":"<jats:p>A new software package called flowFP for the analysis of flow cytometry data is introduced. The package, which is tightly integrated with other Bioconductor software for analysis of flow cytometry, provides tools to transform raw flow cytometry data into a form suitable for direct input into conventional statistical analysis and empirical modeling software tools. The approach of flowFP is to generate a description of the multivariate probability distribution function of flow cytometry data in the form of a \u201cfingerprint.\u201d As such, it is independent of a presumptive functional form for the distribution, in contrast with model-based methods such as Gaussian Mixture Modeling. FlowFP is computationally efficient and able to handle extremely large flow cytometry data sets of arbitrary dimensionality. Algorithms and software implementation of the package are described. Use of the software is exemplified with applications to data quality control and to the automated classification of Acute Myeloid Leukemia.<\/jats:p>","DOI":"10.1155\/2009\/193947","type":"journal-article","created":{"date-parts":[[2009,9,24]],"date-time":"2009-09-24T15:38:44Z","timestamp":1253806724000},"page":"1-11","source":"Crossref","is-referenced-by-count":40,"title":["FlowFP: A Bioconductor Package for Fingerprinting Flow Cytometric Data"],"prefix":"10.1155","volume":"2009","author":[{"given":"Wade T.","family":"Rogers","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, 207 John Morgan Bldg., Philadelphia, PA 19104-6082, USA"}]},{"given":"Herbert A.","family":"Holyst","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, 207 John Morgan Bldg., Philadelphia, PA 19104-6082, USA"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2008.02989.x"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(01)00015-6"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.20156"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.20055"},{"issue":"7","key":"5","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1128\/AEM.02006-08","volume":"75","year":"2009","journal-title":"Applied and Environmental Microbiology"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1038\/nm1371"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.20584"},{"issue":"8","key":"8","first-page":"693","volume":"73","year":"2008","journal-title":"Cytometry Part A"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3148.1999.00187.x"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0320(20010901)45:1<47::AID-CYTO1143>3.0.CO;2-A"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.20545"},{"key":"12","year":"2008"},{"issue":"10","key":"13","doi-asserted-by":"crossref","first-page":"R80","DOI":"10.1186\/gb-2004-5-10-r80","volume":"5","year":"2004","journal-title":"Genome Biology"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-10-106"},{"issue":"5","key":"16","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1093\/ajcp\/100.5.534","volume":"100","year":"1993","journal-title":"American Journal of Clinical Pathology"},{"issue":"6","key":"17","first-page":"548","volume":"44","year":"1996","journal-title":"Rinsho Byori"},{"issue":"11","key":"18","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1038\/sj.leu.2400847","volume":"11","year":"1997","journal-title":"Leukemia"},{"issue":"2","key":"19","first-page":"199","volume":"22","year":"2000","journal-title":"Zhongguo Yi Xue Ke Xue Yuan Xue Bao"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0320(20000215)42:1<1::AID-CYTO1>3.0.CO;2-A"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2257.2003.00489.x"},{"issue":"5","key":"22","doi-asserted-by":"crossref","first-page":"187","DOI":"10.4103\/0019-5359.16254","volume":"59","year":"2005","journal-title":"Indian Journal of Medical Sciences"},{"issue":"4","key":"23","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.4049\/jimmunol.179.4.2627","volume":"179","year":"2007","journal-title":"Journal of Immunology"},{"issue":"1","key":"25","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","volume":"57","year":"1995","journal-title":"Journal of the Royal Statistical Society Series B"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-9-114"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1007\/BF00994018"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.20531"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.20258"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2003.11.016"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.20592"}],"container-title":["Advances in Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/2009\/193947.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2009\/193947.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2009\/193947.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T10:14:14Z","timestamp":1739355254000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/abi\/2009\/193947\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9,24]]},"references-count":29,"alternative-id":["193947","193947"],"URL":"https:\/\/doi.org\/10.1155\/2009\/193947","relation":{},"ISSN":["1687-8027","1687-8035"],"issn-type":[{"value":"1687-8027","type":"print"},{"value":"1687-8035","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,24]]}}}