{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,3]],"date-time":"2024-02-03T20:09:35Z","timestamp":1706990975846},"reference-count":16,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Rheumatology"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>A previously unknown side effect of biphosphonate use is emerging. In a specific patient group on long term biphosphonate therapy stress femur fractures seem to occur. The typical presentation consists of prodromal pain in the affected leg and\/or a discrete cortical thickening on the lateral side of the femur in conventional radiological examination or the presentation with a spontaneous transverse subtrochanteric femur with typical features. We present three cases of this stress fracture in patients on bisphosphonate therapy. One of these patients suffered a bilateral femur fracture of the same type. In our opinion, in patients on bisphosphonate therapy who present with a spontaneous femur fracture, seizing therapy is advisable. In bilateral cases preventive nailing should be considered.<\/jats:p>","DOI":"10.1155\/2009\/253432","type":"journal-article","created":{"date-parts":[[2010,1,27]],"date-time":"2010-01-27T10:31:06Z","timestamp":1264588266000},"page":"1-6","source":"Crossref","is-referenced-by-count":9,"title":["Long-Term Alendronate Use Not without Consequences?"],"prefix":"10.1155","volume":"2009","author":[{"given":"M. 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