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Neuropsychiatric symptoms in persons with 22q11.2 deletion, including obsessive compulsiveness, anxiety, hyperactivity, and one prior case report of TS, have been attributed to low copy number effects on Catechol-O-Methyltransferase (COMT). However, the present unique case of 22q11DupS and TS suggests a more complex relationship involving another gene(s) at or near this locus.<\/jats:p>","DOI":"10.1155\/2009\/361518","type":"journal-article","created":{"date-parts":[[2009,12,22]],"date-time":"2009-12-22T10:30:19Z","timestamp":1261477819000},"page":"1-5","source":"Crossref","is-referenced-by-count":22,"title":["Tourette Syndrome and Klippel-Feil Anomaly in a Child with Chromosome 22q11 Duplication"],"prefix":"10.1155","volume":"2009","author":[{"given":"Raymond A.","family":"Clarke","sequence":"first","affiliation":[{"name":"St George Clinical School, Faculty of Medicine, St George Hospital, University of NSW, Kogarah, NSW 2217, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi Ming","family":"Fang","sequence":"additional","affiliation":[{"name":"St George Clinical School, Faculty of Medicine, St George Hospital, University of NSW, Kogarah, NSW 2217, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish D.","family":"Diwan","sequence":"additional","affiliation":[{"name":"St George Clinical School, Faculty of Medicine, St George Hospital, University of NSW, Kogarah, NSW 2217, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald L.","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Movement Disorders Clinics, Division of Pediatric Neurology, Cincinnati Children's Hospital Medical Center, ML # 11006 - 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