{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:21:00Z","timestamp":1763036460208,"version":"3.41.2"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,10,8]],"date-time":"2009-10-08T00:00:00Z","timestamp":1254960000000},"content-version":"vor","delay-in-days":280,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["AN 331\/3-1","AN 331\/5-1","513700"],"award-info":[{"award-number":["AN 331\/3-1","AN 331\/5-1","513700"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["AN 331\/3-1","AN 331\/5-1","513700"],"award-info":[{"award-number":["AN 331\/3-1","AN 331\/5-1","513700"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Health & Medical Research Council, Australia","award":["AN 331\/3-1","AN 331\/5-1","513700"],"award-info":[{"award-number":["AN 331\/3-1","AN 331\/5-1","513700"]}]},{"name":"Jean-Uhrmacher Foundation","award":["AN 331\/3-1","AN 331\/5-1","513700"],"award-info":[{"award-number":["AN 331\/3-1","AN 331\/5-1","513700"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. To determine whether transplantation of Schwann cells (SCs) overexpressing different isoforms of fibroblast growth factor 2 (FGF\u20102) combined with manual stimulation (MS) of vibrissal muscles improves recovery after facial nerve transection in adult rat.<jats:italic>Procedures<\/jats:italic>. Transected facial nerves were entubulated with collagen alone or collagen plus na\u00efve SCs or transfected SCs. Half of the rats received daily MS. Collateral branching was quantified from motoneuron counts after retrograde labeling from 3 facial nerve branches. Quality assessment of endplate reinnervation was combined with video\u2010based vibrissal function analysis.<jats:italic>Results<\/jats:italic>. There was no difference in the extent of collateral axonal branching. The proportion of polyinnervated motor endplates for either na\u00efve SCs or FGF\u20102 over\u2010expressing SCs was identical. Postoperative MS also failed to improve recovery.<jats:italic>Conclusions<\/jats:italic>. Neither FGF\u20102 isoform changed the extent of collateral branching or polyinnervation of motor endplates; furthermore, this motoneuron response could not be overridden by MS.<\/jats:p>","DOI":"10.1155\/2009\/408794","type":"journal-article","created":{"date-parts":[[2010,3,15]],"date-time":"2010-03-15T14:08:17Z","timestamp":1268662097000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Schwann Cells Overexpressing FGF\u20102 Alone or Combined with Manual Stimulation Do Not Promote Functional Recovery after Facial Nerve Injury"],"prefix":"10.1155","volume":"2009","author":[{"given":"Kirsten","family":"Haastert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Grosheva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srebrina K.","family":"Angelova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orlando","family":"Guntinas-Lichius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanouil","family":"Skouras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joern","family":"Michael","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Grothe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah A.","family":"Dunlop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doychin N.","family":"Angelov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,10,8]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1089\/107632700320748"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2001.7846"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.1997.tb01313.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1994.1041"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.3233\/RNN\u20102009\u20100462"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0142\u20109612(00)00028\u20104"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529\u20108027.2007.00125.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2004.11.007"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00533.2002"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2006.12.001"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2005.12.001"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490230306"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490200306"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/neu.20265"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.3727\/000000003108746821"},{"key":"e_1_2_6_16_2","first-page":"1","article-title":"Axonal branching and recovery of coordinated muscle activity after transection of the facial nerve in adult rats","volume":"180","author":"Angelov D. N.","year":"2005","journal-title":"Advances in Anatomy Embryology and Cell Biology"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2006.12.016"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2008.07.087"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2005.11.1004"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2005.06.020"},{"key":"e_1_2_6_21_2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3233\/RNN-2000-00127","article-title":"Local application of extracellular matrix proteins fails to reduce the number of axonal branches after varying reconstructive surgery on rat facial nerve","volume":"16","author":"Dohm S.","year":"2000","journal-title":"Restorative Neurology and Neuroscience"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.104.4.1097"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(88)90417-X"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2004.09.003"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20166"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.3109\/08977190109001085"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199904060-00035"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2002.8040"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.1986.tb02764.x"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0361\u20109230(00)00411\u20101"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460\u20109568.2005.03877.x"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1385\/MN:27:3:277"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460\u20109568.2002.01971.x"},{"key":"e_1_2_6_34_2","first-page":"235","volume-title":"The Facial Palsies","author":"Greulich M.","year":"2005"},{"key":"e_1_2_6_35_2","first-page":"21","article-title":"Ueber die Degenerations- und Regenerationsvorg\u00e4nge am Nerven nach Verletzungen","volume":"10","author":"B\u00fcngner O.","year":"1891","journal-title":"Beitr\u00e4ge zur Pathologischen Anatomie"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2007.06.023"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20102004\u2010820870"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bioeng.5.011303.120731"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582\u20104934.2006.tb00401.x"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.2174\/156652307780859035"},{"key":"e_1_2_6_41_2","doi-asserted-by":"crossref","unstructured":"JungnickelJ. HaastertK. GrzybekM.et al. Mice lacking basic fibroblast growth factor showed faster sensory recovery Experimental Neurology. In presshttps:\/\/doi.org\/10.1016\/j.expneurol.2009.06.003 EID2-s2.0-67649212135.","DOI":"10.1016\/j.expneurol.2009.06.003"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306\u20104522(82)90239\u20101"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006\u20108993(81)90013\u20105"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1359\u20106101(97)00033\u20106"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/265459a0"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(81)90891-X"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2008.100"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2009\/408794.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2009\/408794.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2009\/408794","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T13:11:38Z","timestamp":1739970698000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2009\/408794"}},"subtitle":[],"editor":[{"given":"George","family":"Perry","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2009,1]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["10.1155\/2009\/408794"],"URL":"https:\/\/doi.org\/10.1155\/2009\/408794","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"type":"print","value":"2314-6133"},{"type":"electronic","value":"2314-6141"}],"subject":[],"published":{"date-parts":[[2009,1]]},"assertion":[{"value":"2009-02-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-07-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-10-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"408794"}}