{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:16:03Z","timestamp":1793394963896,"version":"4.5.0"},"reference-count":6,"publisher":"Wiley","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Medicine"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. The preferred treatment method of most hydatidiform moles is suction aspiration. In rare circumstances uterine abnormalities may preclude surgical treatment.<jats:italic>Case<\/jats:italic>. We report a case of complete molar pregnancy successfully treated with methotrexate followed by EMA\/CO. A 38-year-old woman with a complete hydatidiform mole and multiple uterine fibroids underwent a failed attempt at suction aspiration. Following treatment with methotrexate, a nonmetastatic persistent trophoblastic tumour developed. Six cycles of EMA\/CO led to complete remission.<jats:italic>Conclusion<\/jats:italic>. We propose that primary treatment of molar pregnancies with chemotherapy is a useful treatment option in cases where uterine abnormalities interfere with suction aspiration.<\/jats:p>","DOI":"10.1155\/2009\/454161","type":"journal-article","created":{"date-parts":[[2009,5,19]],"date-time":"2009-05-19T11:53:35Z","timestamp":1242734015000},"page":"1-3","source":"Crossref","is-referenced-by-count":4,"title":["Successful Primary Treatment of a Hydatidiform Mole with Methotrexate and EMA\/CO"],"prefix":"10.1155","volume":"2009","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5019-5924","authenticated-orcid":true,"given":"M.","family":"De Vos","sequence":"first","affiliation":[{"name":"Department of Gynaecology, Academic Hospital, Brussels Free University - (VUB), UZ Brussel, 1090 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Leunen","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Academic Hospital, Brussels Free University - (VUB), UZ Brussel, 1090 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Fontaine","sequence":"additional","affiliation":[{"name":"Department of Oncology, Academic Hospital, Brussels Free University - (VUB), UZ Brussel, 1090 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ph.","family":"De Sutter","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Academic Hospital, Brussels Free University - (VUB), UZ Brussel, 1090 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(03)01245-2"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199612053352306"},{"issue":"6, part 1","key":"3","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/0002-9378(88)90360-2","volume":"158","year":"1988","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2000.5839"},{"issue":"7","key":"5","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1111\/j.1471-0528.1994.tb13661.x","volume":"101","year":"1994","journal-title":"British Journal of Obstetrics and Gynaecology"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/S1521-6934(03)00098-1"}],"container-title":["Case Reports in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crim\/2009\/454161.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crim\/2009\/454161.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crim\/2009\/454161.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,18]],"date-time":"2017-06-18T16:02:08Z","timestamp":1497801728000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/crim\/2009\/454161\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":6,"alternative-id":["454161","454161"],"URL":"https:\/\/doi.org\/10.1155\/2009\/454161","relation":{},"ISSN":["1687-9627","1687-9635"],"issn-type":[{"value":"1687-9627","type":"print"},{"value":"1687-9635","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}