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We develop a\nnew feature selection method called <jats:italic>Biological Pathway-based Feature Selection (BPFS)<\/jats:italic> for microarray data. Unlike most of the existing methods,\nour method integrates signaling and gene regulatory pathways with gene\nexpression data to minimize the chance of overfitting of the method and to\nimprove the test accuracy. Thus, BPFS selects a biologically meaningful feature\nset that is minimally redundant. Our experiments on published breast\ncancer datasets demonstrate that all of the top 20 genes found by our method\nare associated with cancer. Furthermore, the classification accuracy of our\nsignature is up to 18% better than that of vant Veers 70 gene signature,\nand it is up to 8% better accuracy than the best published feature selection\nmethod, I-RELIEF.<\/jats:p>","DOI":"10.1155\/2009\/532989","type":"journal-article","created":{"date-parts":[[2010,3,3]],"date-time":"2010-03-03T15:29:07Z","timestamp":1267630147000},"page":"1-16","source":"Crossref","is-referenced-by-count":12,"title":["Pathway-Based Feature Selection Algorithm for Cancer Microarray Data"],"prefix":"10.1155","volume":"2009","author":[{"given":"Nirmalya","family":"Bandyopadhyay","sequence":"first","affiliation":[{"name":"Computer and Information Science and Engineering, University of Florida, Gainesville, FL 32611, USA"}]},{"given":"Tamer","family":"Kahveci","sequence":"additional","affiliation":[{"name":"Computer and Information Science and Engineering, University of Florida, Gainesville, FL 32611, USA"}]},{"given":"Steve","family":"Goodison","sequence":"additional","affiliation":[{"name":"Anderson Cancer Center Orlando, Cancer Research Institute Orlando, FL 32827, USA"}]},{"given":"Y.","family":"Sun","sequence":"additional","affiliation":[{"name":"Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, FL 32611, USA"}]},{"given":"Sanjay","family":"Ranka","sequence":"additional","affiliation":[{"name":"Computer and Information Science and Engineering, University of Florida, Gainesville, FL 32611, 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