{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T01:53:15Z","timestamp":1781315595534,"version":"3.54.1"},"reference-count":112,"publisher":"Wiley","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI043596"],"award-info":[{"award-number":["AI043596"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Interdisciplinary Perspectives on Infectious Diseases"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p><jats:italic>Entamoeba histolytica<\/jats:italic>is an invasive intestinal pathogenic parasitic protozoan that causes amebiasis. It must be distinguished from<jats:italic>Entamoeba dispar<\/jats:italic>and<jats:italic>E. moshkovskii<\/jats:italic>, nonpathogenic commensal parasites of the human gut lumen that are morphologically identical to<jats:italic>E. histolytica<\/jats:italic>. Detection of specific<jats:italic>E. histolytica<\/jats:italic>antigens in stools is a fast, sensitive technique that should be considered as the method of choice. Stool real-time PCR is a highly sensitive and specific technique but its high cost make it unsuitable for use in endemic areas where there are economic constraints. Serology is an important component of the diagnosis of intestinal and especially extraintestinal amebiasis as it is a sensitive test that complements the detection of the parasite antigens or DNA. Circulating Gal\/GalNac lectin antigens can be detected in the serum of patients with untreated amoebic liver abscess. 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