{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T15:25:28Z","timestamp":1746804328927,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100004099","name":"La Ligue Contre le Cancer","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2009]]},"abstract":"In view of the important oncogenic action of phospholipaseA<\/mml:mtext>2<\/mml:mn><\/mml:msub>(<\/mml:mo>PLA<\/mml:mtext><\/mml:mrow>2<\/mml:mn><\/mml:msub><\/mml:mrow>)<\/mml:mo><\/mml:mrow><\/mml:mrow><\/mml:math>we investigatedPLA<\/mml:mtext><\/mml:mrow>2<\/mml:mn><\/mml:msub><\/mml:mrow><\/mml:math>transcripts in human meningiomas. Real-time PCR was used to investigatePLA<\/mml:mtext><\/mml:mrow>2<\/mml:mn><\/mml:msub><\/mml:mrow><\/mml:math>transcripts in 26 human meningioma tumors. Results indicated that threeCa<\/mml:mtext><\/mml:mrow>2<\/mml:mn>+<\/mml:mo><\/mml:mrow><\/mml:msup><\/mml:mrow><\/mml:math>-dependent high molecular weightPLA<\/mml:mtext><\/mml:mrow>2<\/mml:mn><\/mml:msub><\/mml:mrow><\/mml:math>(PLA<\/mml:mtext><\/mml:mrow>2<\/mml:mn><\/mml:msub><\/mml:mrow><\/mml:math>-IVA,PLA<\/mml:mtext><\/mml:mrow>2<\/mml:mn><\/mml:msub><\/mml:mrow><\/mml:math>-IVB,PLA<\/mml:mtext><\/mml:mrow>2<\/mml:mn><\/mml:msub><\/mml:mrow><\/mml:math>-IVC), oneCa<\/mml:mtext><\/mml:mrow>2<\/mml:mn>+<\/mml:mo><\/mml:mrow><\/mml:msup><\/mml:mrow><\/mml:math>-independent high molecular weightPLA<\/mml:mtext><\/mml:mrow>2<\/mml:mn><\/mml:msub><\/mml:mrow><\/mml:math>(PLA<\/mml:mtext><\/mml:mrow>2<\/mml:mn><\/mml:msub><\/mml:mrow><\/mml:math>-VI) and five low molecular weight secreted forms ofPLA<\/mml:mtext><\/mml:mrow>2<\/mml:mn><\/mml:msub><\/mml:mrow><\/mml:math>(PLA<\/mml:mtext><\/mml:mrow>2<\/mml:mn><\/mml:msub><\/mml:mrow><\/mml:math>-IB,PLA<\/mml:mtext><\/mml:mrow>2<\/mml:mn><\/mml:msub><\/mml:mrow><\/mml:math>-IIA,PLA<\/mml:mtext><\/mml:mrow>2<\/mml:mn><\/mml:msub><\/mml:mrow><\/mml:math>-III,PLA<\/mml:mtext><\/mml:mrow>2<\/mml:mn><\/mml:msub><\/mml:mrow><\/mml:math>-V, andPLA<\/mml:mtext><\/mml:mrow>2<\/mml:mn><\/mml:msub><\/mml:mrow><\/mml:math>-XII) are expressed withPLA<\/mml:mtext><\/mml:mrow>2<\/mml:mn><\/mml:msub><\/mml:mrow><\/mml:math>-IVA,PLA<\/mml:mtext><\/mml:mrow>2<\/mml:mn><\/mml:msub><\/mml:mrow><\/mml:math>-IVB,PLA<\/mml:mtext><\/mml:mrow>2<\/mml:mn><\/mml:msub><\/mml:mrow><\/mml:math>-VI, andPLA<\/mml:mtext><\/mml:mrow>2<\/mml:mn><\/mml:msub><\/mml:mrow><\/mml:math>-XIIA as the major expressed forms.PLA<\/mml:mtext><\/mml:mrow>2<\/mml:mn><\/mml:msub><\/mml:mrow><\/mml:math>-IIE,PLA<\/mml:mtext><\/mml:mrow>2<\/mml:mn><\/mml:msub><\/mml:mrow><\/mml:math>-IIF,PLA<\/mml:mtext><\/mml:mrow>2<\/mml:mn><\/mml:msub><\/mml:mrow><\/mml:math>-IVD, andPLA<\/mml:mtext><\/mml:mrow>2<\/mml:mn><\/mml:msub><\/mml:mrow><\/mml:math>-XIIB are not detected. Plasma (PLA<\/mml:mtext><\/mml:mrow>2<\/mml:mn><\/mml:msub><\/mml:mrow><\/mml:math>-VIIA) and intracellular (PLA<\/mml:mtext><\/mml:mrow>2<\/mml:mn><\/mml:msub><\/mml:mrow><\/mml:math>-VIIB) platelet-activating factor acetylhydrolase transcripts are expressed in human meningiomas. However no difference was found forPLA<\/mml:mtext><\/mml:mrow>2<\/mml:mn><\/mml:msub><\/mml:mrow><\/mml:math>transcript amounts in relation to the tumor grade, the subtype of meningiomas, the presence of inflammatory infiltrated cells, of an associated edema, mitosis, brain invasion, vascularisation or necrosis. In conclusion numerous genes encoding multiples forms ofPLA<\/mml:mtext><\/mml:mrow>2<\/mml:mn><\/mml:msub><\/mml:mrow><\/mml:math>are expressed in meningiomas where they might act on the phospholipid remodeling and on the local eicosanoid and\/or cytokine networks.<\/jats:p>","DOI":"10.1155\/2009\/689430","type":"journal-article","created":{"date-parts":[[2010,3,21]],"date-time":"2010-03-21T11:30:22Z","timestamp":1269171022000},"page":"1-8","source":"Crossref","is-referenced-by-count":3,"title":["Analysis of SeveralPLA<\/mml:mtext><\/mml:mrow>2<\/mml:mtext><\/mml:msub><\/mml:mrow><\/mml:math>mRNA in Human Meningiomas"],"prefix":"10.1155","volume":"2009","author":[{"given":"Yves","family":"Denizot","sequence":"first","affiliation":[{"name":"UMR CNRS 6101, Centre National de la Recherche Scientifique, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Limoges, 2 rue Dr. Marcland, 87025 Limoges, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"De Armas","sequence":"additional","affiliation":[{"name":"Service d'Anatomie Pathologique, CHU Dupuytren, 87045 Limoges, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karine","family":"Durand","sequence":"additional","affiliation":[{"name":"Service d'Anatomie Pathologique, CHU Dupuytren, 87045 Limoges, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine","family":"Robert","sequence":"additional","affiliation":[{"name":"Service d'Anatomie Pathologique, CHU Dupuytren, 87045 Limoges, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Jacques","family":"Moreau","sequence":"additional","affiliation":[{"name":"Service de Neurochirurgie, CHU Dupuytren, 87045 Limoges, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Caire","sequence":"additional","affiliation":[{"name":"Service de Neurochirurgie, CHU Dupuytren, 87045 Limoges, 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