{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:06:27Z","timestamp":1761512787022},"reference-count":12,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Medicine"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>Polyarteritis nodosa (PAN) is a systemic vasculitis whose severe forms are treated with glucocorticoids and cyclophosphamide. Refractory patients are exposed to many complications, notably accelerated atherosclerosis. We report a case report of 71-year-old man followed for polyarteritis nodosa refractory to glucocorticoids and cyclosphosphamide. Systemic vasculitis relapses are followed to accelerated atherosclerosis: severe ischemic lesions led to amputation of lower limbs. Remission of refractory PAN is obtained with rituximab. Disappearance of biological inflammatory is allowed to regression of ischemic lesions in upper limbs. In this situation, we recommend a systematic vascular work-up for patients suffered from refractory vasculitis. On the other hand, therapeutic trials are needed to determine the real efficacy and place of rituximab in the treatment of polyarteritis nodosa.<\/jats:p>","DOI":"10.1155\/2009\/738293","type":"journal-article","created":{"date-parts":[[2010,3,14]],"date-time":"2010-03-14T15:30:07Z","timestamp":1268580607000},"page":"1-3","source":"Crossref","is-referenced-by-count":19,"title":["Rituximab Efficacy during a Refractory Polyarteritis Nodosa Flare"],"prefix":"10.1155","volume":"2009","author":[{"given":"Emmanuel","family":"Ribeiro","sequence":"first","affiliation":[{"name":"Service de M\u00e9decine Interne, H\u00f4pital Saint-Andr\u00e9, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Cressend","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, H\u00f4pital Saint-Andr\u00e9, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, 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