{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:35:32Z","timestamp":1753886132745,"version":"3.41.2"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,2,11]],"date-time":"2009-02-11T00:00:00Z","timestamp":1234310400000},"content-version":"vor","delay-in-days":41,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KFO 170"],"award-info":[{"award-number":["KFO 170"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["PPAR Research"],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:p>A major genomic region involved in Wegener\u2032s granulomatosis includes the gene for retinoid receptor beta (<jats:italic>RXRB<\/jats:italic>) which forms heterodimers with peroxisome proliferator\u2010activated receptors (PPARs). It is unclear whether this association directly arises from the <jats:italic>RXRB<\/jats:italic> allele(s) or via a linked variation.\nIn order to reveal any hitherto unknown and potentially disease\u2010relevant variation of the <jats:italic>RXRB<\/jats:italic> gene, we have genotyped four tagging SNPs of this genomic region and have directly sequenced selected WG patients and controls representing disease\u2010associated haplotypes. Additionally, we have genotyped 2 SNPs each in the genes for PPAR<jats:italic>\u03b1<\/jats:italic> and PPAR<jats:italic>\u03b3<\/jats:italic> (<jats:italic>PPARA<\/jats:italic> and <jats:italic>PPARG<\/jats:italic>). Hence, we confirmed the strong association of the <jats:italic>RXRB<\/jats:italic> locus with WG but could not reveal any novel variation in <jats:italic>RXRB<\/jats:italic>. None of the <jats:italic>PPARA<\/jats:italic> and <jats:italic>PPARG<\/jats:italic> SNPs showed association with WG. Moreover, no epistatic effect was seen between <jats:italic>RXRB<\/jats:italic> and <jats:italic>PPARA<\/jats:italic>\/<jats:italic>PPARG<\/jats:italic> alleles. \nThese results do not support an etiopathological role of PPAR in WG. Analyses of further genes functionally linked to RXRB may provide additional data useful to evaluate the <jats:italic>RXRB<\/jats:italic> association found in WG.<\/jats:p>","DOI":"10.1155\/2009\/786781","type":"journal-article","created":{"date-parts":[[2009,2,15]],"date-time":"2009-02-15T06:58:45Z","timestamp":1234681125000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Genetic Variability of RXRB, PPARA, and  PPARG in Wegener\u2032s Granulomatosis"],"prefix":"10.1155","volume":"2009","author":[{"given":"Stefan","family":"Wieczorek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Knaup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang L.","family":"Gross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg T.","family":"Epplen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,11]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_6_1_2","DOI":"10.1007\/s12016-007-8056-8"},{"doi-asserted-by":"publisher","key":"e_1_2_6_2_2","DOI":"10.1007\/s00439-004-1092-z"},{"doi-asserted-by":"publisher","key":"e_1_2_6_3_2","DOI":"10.1136\/ard.2007.077693"},{"doi-asserted-by":"publisher","key":"e_1_2_6_4_2","DOI":"10.1186\/1471-2350-7-21"},{"doi-asserted-by":"publisher","key":"e_1_2_6_5_2","DOI":"10.1038\/384039a0"},{"doi-asserted-by":"publisher","key":"e_1_2_6_6_2","DOI":"10.1038\/34178"},{"doi-asserted-by":"publisher","key":"e_1_2_6_7_2","DOI":"10.1093\/ajcn\/87.6.1926"},{"doi-asserted-by":"publisher","key":"e_1_2_6_8_2","DOI":"10.1253\/circj.72.551"},{"doi-asserted-by":"publisher","key":"e_1_2_6_9_2","DOI":"10.1016\/j.atherosclerosis.2007.10.004"},{"doi-asserted-by":"publisher","key":"e_1_2_6_10_2","DOI":"10.1136\/ard.2004.029033"},{"doi-asserted-by":"publisher","key":"e_1_2_6_11_2","DOI":"10.1002\/art.1780370206"},{"doi-asserted-by":"publisher","key":"e_1_2_6_12_2","DOI":"10.1093\/bioinformatics\/bth457"},{"doi-asserted-by":"publisher","key":"e_1_2_6_13_2","DOI":"10.1186\/1471-2350-7-34"}],"container-title":["PPAR Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ppar\/2009\/786781.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ppar\/2009\/786781.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2009\/786781","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T14:29:51Z","timestamp":1718634591000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2009\/786781"}},"subtitle":[],"editor":[{"given":"Mostafa","family":"Badr","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2009,1]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["10.1155\/2009\/786781"],"URL":"https:\/\/doi.org\/10.1155\/2009\/786781","archive":["Portico"],"relation":{},"ISSN":["1687-4757","1687-4765"],"issn-type":[{"type":"print","value":"1687-4757"},{"type":"electronic","value":"1687-4765"}],"subject":[],"published":{"date-parts":[[2009,1]]},"assertion":[{"value":"2008-08-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-01-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-02-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"786781"}}