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In this paper, we propose an original extension of the NAS\u2010RIF restoration technique by using information fusion as prior information with application in SPECT medical imaging. That extension allows the restoration process to be constrained by efficiently incorporating, within the NAS\u2010RIF method, a regularization term which stabilizes the inverse solution. Our restoration method is constrained by anatomical information extracted from a high resolution anatomical procedure such as magnetic resonance imaging (MRI). This structural anatomy\u2010based regularization term uses the result of an unsupervised Markovian segmentation obtained after a preliminary registration step between the MRI and SPECT data volumes from each patient. This method was successfully tested on 30 pairs of brain MRI and SPECT acquisitions from different subjects and on Hoffman and Jaszczak SPECT phantoms. The experiments demonstrated that the method performs better, in terms of signal\u2010to\u2010noise ratio, than a classical supervised restoration approach using a Metz filter.<\/jats:p>","DOI":"10.1155\/2009\/843160","type":"journal-article","created":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T16:03:01Z","timestamp":1254412981000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Image Restoration Using Functional and Anatomical Information Fusion with Application to SPECT\u2010MRI Images"],"prefix":"10.1155","volume":"2009","author":[{"given":"S.","family":"Benameur","sequence":"first","affiliation":[]},{"given":"M.","family":"Mignotte","sequence":"additional","affiliation":[]},{"given":"J.","family":"Meunier","sequence":"additional","affiliation":[]},{"given":"J.-P.","family":"Soucy","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2009,10]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1109\/TNS.2005.862959"},{"key":"e_1_2_8_2_2","first-page":"77","article-title":"Determination of the optimum filter function for Tc99m-sastamibi myocardial perfusion SPECT imaging","volume":"20","author":"Rajabi H.","year":"2005","journal-title":"Indian Journal of Nuclear Medicine"},{"key":"e_1_2_8_3_2","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1109\/10.821781","article-title":"Three-dimensional blind deconvolution of SPECT images","volume":"4","author":"Mignotte M.","year":"2000","journal-title":"IEEE Transactions on Biomedical Engineering"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1109\/78.655423"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1109\/42.251117"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1109\/42.363105"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1109\/42.650872"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2005.846850"},{"key":"e_1_2_8_9_2","doi-asserted-by":"crossref","unstructured":"BenameurS. 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