{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T10:32:11Z","timestamp":1789813931463,"version":"4.0.1"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"United States Public Health Service","award":["R01 DE10728"],"award-info":[{"award-number":["R01 DE10728"]}]},{"name":"United States Public Health Service","award":["R01 DK56597"],"award-info":[{"award-number":["R01 DK56597"]}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","award":["R01 DE10728"],"award-info":[{"award-number":["R01 DE10728"]}],"id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","award":["R01 DK56597"],"award-info":[{"award-number":["R01 DK56597"]}],"id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Interdisciplinary Perspectives on Infectious Diseases"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>Periodontal disease is one of the most common infectious diseases of humans. Immune responses to infection trigger loss of alveolar bone from the jaw and eventual tooth loss. We investigated the contribution of B cell IgD to alveolar bone loss by comparing the response of B cell normal BALB\/cJ mice and IgD deficient BALB\/c-Igh-<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:msup><mml:mn>5<\/mml:mn><mml:mrow><mml:mo>\u2212\/\u2212<\/mml:mo><mml:mtext>J<\/mml:mtext><\/mml:mrow><\/mml:msup><\/mml:mrow><\/mml:math>mice to oral infection with<jats:italic>Porphyromonas gingivalis<\/jats:italic>, a gram-negative periodontopathic bacterium from humans.<jats:italic>P. gingivalis<\/jats:italic>-infected normal mice lost bone. Specific antibody to<jats:italic>P. gingivalis<\/jats:italic>was lower and oral colonization was higher in IgD deficient mice; yet bone loss was completely absent. Infection increased the proportion of CD<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:msup><mml:mrow><mml:mn>69<\/mml:mn><\/mml:mrow><mml:mo>+<\/mml:mo><\/mml:msup><\/mml:mrow><\/mml:math>activated B cells and CD<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:msup><mml:mn>4<\/mml:mn><mml:mo>+<\/mml:mo><\/mml:msup><\/mml:mrow><\/mml:math>T cells in immune normal mice compared to IgD deficient mice. These data suggest that IgD is an important mediator of alveolar bone resorption, possibly through antigen-specific coactivation of B cells and CD<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:msup><mml:mn>4<\/mml:mn><mml:mo>+<\/mml:mo><\/mml:msup><\/mml:mrow><\/mml:math>T cells.<\/jats:p>","DOI":"10.1155\/2009\/864359","type":"journal-article","created":{"date-parts":[[2009,10,25]],"date-time":"2009-10-25T15:30:05Z","timestamp":1256484605000},"page":"1-6","source":"Crossref","is-referenced-by-count":33,"title":["B Cell IgD Deletion Prevents Alveolar Bone Loss Following Murine Oral Infection"],"prefix":"10.1155","volume":"2009","author":[{"given":"Pamela J.","family":"Baker","sequence":"first","affiliation":[{"name":"Biology Department, Bates College, Lewiston, ME 04240, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole Ryan","family":"Boutaugh","sequence":"additional","affiliation":[{"name":"Biology Department, Bates College, 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