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Chronic liver injury encompasses a wide spectrum of diseases due to HCV and HBV coinfection, drug\u2010related toxicity, and NASH. HIV\u2010infected patients who are receiving treatment present with a high prevalence of metabolic complications and lipodystrophy. Those patients are at high risk of nonalcoholic fatty liver disease, the liver feature of the metabolic syndrome. This review will focus on (1) the liver injuries in HIV\u2010infected patients; (2) both the current experimental and human data regarding PPAR and liver diseases; (3) the interactions between HIV and PPAR; (4) the potential use of PPAR agonists for the management of HIV\u2010related liver diseases.<\/jats:p>","DOI":"10.1155\/2009\/906167","type":"journal-article","created":{"date-parts":[[2009,4,16]],"date-time":"2009-04-16T06:36:07Z","timestamp":1239863767000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["PPAR and Liver Injury in HIV\u2010Infected Patients"],"prefix":"10.1155","volume":"2009","author":[{"given":"Maud","family":"Lemoine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Capeau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence","family":"Serfaty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,4,15]]},"reference":[{"key":"e_1_2_5_1_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31817efb54"},{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/1074-5521(95)90045-4"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.33666"},{"key":"e_1_2_5_4_2","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1128\/jcm.31.10.2679-2682.1993","article-title":"Quantitative evaluation of hepatitis C virus RNA in patients with concurrent human immunodeficiency virus \ninfections","volume":"31","author":"Sherman K. 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