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However, they rely on\nEuclidean distances that fail to reflect accurately the proximities\namong sample profiles. Then, non\u2010Euclidean dissimilarities\nprovide additional information that should be considered\nto reduce the misclassification errors. \nIn this paper, we incorporate in the <jats:italic>\u03bd<\/jats:italic>\u2010SVM algorithm a\nlinear combination of non\u2010Euclidean dissimilarities. The\nweights of the combination are learnt in a (Hyper\nReproducing Kernel Hilbert Space) HRKHS using a Semidefinite\nProgramming algorithm. This approach allows us to incorporate\na smoothing term that penalizes the complexity of the\nfamily of distances and avoids overfitting. The experimental results suggest that the method proposed\nhelps to reduce the misclassification errors in several\nhuman cancer problems.<\/jats:p>","DOI":"10.1155\/2009\/906865","type":"journal-article","created":{"date-parts":[[2009,6,21]],"date-time":"2009-06-21T13:33:50Z","timestamp":1245591230000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Combining Dissimilarities in a Hyper Reproducing Kernel Hilbert Space for Complex Human Cancer Prediction"],"prefix":"10.1155","volume":"2009","author":[{"given":"Manuel","family":"Mart\u00edn-Merino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1ngela","family":"Blanco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"De Las Rivas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,6,21]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001195"},{"volume-title":"Statistical Learning Theory","year":"1998","author":"Vapnik V.","key":"e_1_2_7_2_2"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/16.10.906"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102105\u20108\u2010S8\u2010S3"},{"key":"e_1_2_7_5_2","unstructured":"TsudaK. 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