{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:09:28Z","timestamp":1791050968058,"version":"4.1.0"},"reference-count":22,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>We investigated the effects of clopidogrel on reperfusion and inflammatory process in STEMI. A total of 175 STEMI patients with similar clinical characteristics were included to this study. One was the standard pharmacological reperfusion therapy group (group 1,<jats:italic>n<\/jats:italic>: 90), who received 300\u2009mg aspirin, 70\u2009U\/kg bolus, and 12\u2009U\/kg\/hr continuous infusion of unfractioned heparin and accelerated t-PA. Clopidogrel 450\u2009mg loading and 75\u2009mg\/d thereafter was added to standard reperfusion therapy in the other group (group 2,<jats:italic>n<\/jats:italic>: 85). The ST-segment resolution, CK-MB, and high-sensitive CRP (hs-CRP) parameters were measured. Complete ST resolution was observed in 32 patients (36.8%) in group 1 and 53 patients (63.8%) in group 2 (). Also in the first 24 hours, the CK-MB levels of patients in group 1 were significantly higher than those of group 2 (). The hs-CRP values were greater in group 1 than group 2 at 48th hour (gruop 1: \u2009mg\/L, group 2: \u2009mg\/L; ). We concluded that adding clopidogrel to standard treatment in STEMI patients provided early reperfusion and suppression of inflammatory response.<\/jats:p>","DOI":"10.1155\/2009\/932515","type":"journal-article","created":{"date-parts":[[2009,4,12]],"date-time":"2009-04-12T14:42:57Z","timestamp":1239547377000},"page":"1-5","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy of Clopidrogel on Reperfusion and High-Sensitivity C-Reactive Protein in Patients with Acute Myocardial Infarction"],"prefix":"10.1155","volume":"2009","author":[{"given":"Mehmet","family":"Akbulut","sequence":"first","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine, F\u0131rat University, 23100 Elaz\u0131\u011f, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makbule","family":"Kutlu","sequence":"additional","affiliation":[{"name":"Cardiology Clinic, Harput State Hospital, 23110 Elaz\u0131\u011f, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y\u0131lmaz","family":"Ozbay","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine, F\u0131rat University, 23100 Elaz\u0131\u011f, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veli","family":"Polat","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine, F\u0131rat University, 23100 Elaz\u0131\u011f, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Nail","family":"Bilen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine, F\u0131rat University, 23100 Elaz\u0131\u011f, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adil","family":"Baydas","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine, F\u0131rat University, 23100 Elaz\u0131\u011f, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yakup","family":"Altas","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine, F\u0131rat University, 23100 Elaz\u0131\u011f, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"issue":"1","key":"1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1136\/hrt.77.1.11","volume":"77","year":"1997","journal-title":"Heart"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00443-X"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050522"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.595397"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67660-X"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl317"},{"key":"7","volume-title":"ST-elevation myocardial infarction: management","year":"2008"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)00736-5"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.10.1224"},{"issue":"21","key":"10","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1161\/01.CIR.99.21.2720","volume":"99","year":"1999","journal-title":"Circulation"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000019581.22812.B2"},{"issue":"3","key":"12","first-page":"488","volume":"88","year":"2002","journal-title":"Thrombosis and Haemostasis"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2002.122018"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(01)01813-6"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.04.035"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2003.11.048"},{"issue":"3","key":"17","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1161\/01.CIR.73.3.418","volume":"73","year":"1986","journal-title":"Circulation"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.59.2.196"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1038\/35393"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1038\/nrd985"},{"issue":"2","key":"21","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1161\/01.CIR.96.2.396","volume":"96","year":"1997","journal-title":"Circulation"},{"key":"22","volume-title":"Percutaneous coronary and valvular intervention","year":"2008"}],"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2009\/932515.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2009\/932515.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2009\/932515.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,18]],"date-time":"2017-06-18T18:47:40Z","timestamp":1497811660000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/mi\/2009\/932515\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":22,"alternative-id":["932515","932515"],"URL":"https:\/\/doi.org\/10.1155\/2009\/932515","relation":{},"ISSN":["0962-9351","1466-1861"],"issn-type":[{"value":"0962-9351","type":"print"},{"value":"1466-1861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}