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The type of host immune response against<jats:italic>H. pylori<\/jats:italic>, particularly the cytolytic effector functions of T cells, is crucial for the outcome of the infection. T cells are potentially able to kill a target via different mechanisms, such as perforins or Fas-Fas ligand interaction. In<jats:italic>H. pylori<\/jats:italic>-infected patients with gastric autoimmunity cytolytic T cells, that cross-recognize different epitopes of<jats:italic>H. pylori<\/jats:italic>proteins and -ATPase autoantigen, infiltrate the gastric mucosa and lead to gastric atrophy via long-lasting activation of Fas ligand-mediated appotosis and perforin-induced cytotoxicity. On the other hand, gastric T cells from MALT lymphoma exhibit defective perforin- and Fas-Fas ligand-mediated killing of B cells, with consequent abnormal help for B-cell proliferation, suggesting that deregulated and exhaustive<jats:italic>H. pylori<\/jats:italic>-induced T cell-dependent B-cell activation can support both the onset and the promotion of low-grade B-cell lymphoma.<\/jats:p>","DOI":"10.1155\/2010\/104918","type":"journal-article","created":{"date-parts":[[2010,6,22]],"date-time":"2010-06-22T14:35:19Z","timestamp":1277217319000},"page":"1-10","source":"Crossref","is-referenced-by-count":41,"title":["Cytotoxic T Cells in<i>H. pylori<\/i>-Related Gastric Autoimmunity and Gastric Lymphoma"],"prefix":"10.1155","volume":"2010","author":[{"given":"Mathijs P.","family":"Bergman","sequence":"first","affiliation":[{"name":"Section Molecular Microbiology, Department of Molecular Cell Biology, VU University, De Boelelaan 1085, 1081 HV, Amsterdam, The 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