{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:28:41Z","timestamp":1791329321012,"version":"4.3.1"},"reference-count":66,"publisher":"Wiley","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/D000564\/1"],"award-info":[{"award-number":["BB\/D000564\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["G0501107"],"award-info":[{"award-number":["G0501107"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["BB\/D000564\/1"],"award-info":[{"award-number":["BB\/D000564\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["G0501107"],"award-info":[{"award-number":["G0501107"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Microbiology"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p><jats:italic>Brucella<\/jats:italic>species are the causative agents of one of the most prevalent zoonotic diseases: brucellosis. Infections by<jats:italic>Brucella<\/jats:italic>species cause major economic losses in agriculture, leading to abortions in infected animals and resulting in a severe, although rarely lethal, debilitating disease in humans.<jats:italic>Brucella<\/jats:italic>species persist as intracellular pathogens that manage to effectively evade recognition by the host's immune system. Sugar-modified components in the<jats:italic>Brucella<\/jats:italic>cell envelope play an important role in their host interaction.<jats:italic>Brucella<\/jats:italic>lipopolysaccharide (LPS), unlike<jats:italic>Escherichia coli<\/jats:italic>LPS, does not trigger the host's innate immune system.<jats:italic>Brucella<\/jats:italic>produces cyclic<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>\u03b2<\/mml:mi><\/mml:math>-1,2-glucans, which are important for targeting them to their replicative niche in the endoplasmic reticulum within the host cell. This paper will focus on the role of LPS and cyclic<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>\u03b2<\/mml:mi><\/mml:math>-1,2-glucans in<jats:italic>Brucella<\/jats:italic>-mammalian infections and discuss the use of mutants, within the biosynthesis pathway of these cell envelope structures, in vaccine development.<\/jats:p>","DOI":"10.1155\/2010\/124509","type":"journal-article","created":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T19:36:03Z","timestamp":1291232163000},"page":"1-12","source":"Crossref","is-referenced-by-count":57,"title":["Importance of Lipopolysaccharide and Cyclic<i>\u03b2<\/i>-1,2-Glucans in<i>Brucella<\/i>-Mammalian Infections"],"prefix":"10.1155","volume":"2010","author":[{"given":"Andreas F.","family":"Haag","sequence":"first","affiliation":[{"name":"School of Medicine & Dentistry, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamila K.","family":"Myka","sequence":"additional","affiliation":[{"name":"School of Medicine & Dentistry, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus F. F.","family":"Arnold","sequence":"additional","affiliation":[{"name":"School of Medicine & Dentistry, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Caro-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"School of Medicine & Dentistry, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail P.","family":"Ferguson","sequence":"additional","affiliation":[{"name":"School of Medicine & Dentistry, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(06)70382-6"},{"issue":"2","key":"2","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1093\/clinids\/21.2.283","volume":"21","year":"1995","journal-title":"Clinical Infectious Diseases"},{"key":"3","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1093\/infdis\/27.3.173","volume":"27","year":"1920","journal-title":"Journal of Infectious Diseases"},{"issue":"5","key":"4","doi-asserted-by":"crossref","first-page":"491","DOI":"10.2105\/AJPH.21.5.491","volume":"21","year":"1931","journal-title":"American Journal of Public Health"},{"issue":"4","key":"5","first-page":"579","volume":"48","year":"1968","journal-title":"The Cornell Veterinarian"},{"issue":"3","key":"6","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1017\/S0022172400044612","volume":"54","year":"1956","journal-title":"Journal of Hygiene"},{"issue":"69","key":"7","first-page":"947","volume":"18","year":"1957","journal-title":"American Journal of Veterinary Research"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1099\/ijs.0.65356-0"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1099\/ijs.0.011148-0"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1099\/ijs.0.65269-0"},{"issue":"2","key":"11","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3201\/eid0302.970219","volume":"3","year":"1997","journal-title":"Emerging Infectious Diseases"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1017\/S1462399407000543"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7400689"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2004.07.010"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2859-5-13"},{"issue":"8","key":"16","doi-asserted-by":"crossref","first-page":"4048","DOI":"10.1128\/IAI.67.8.4048-4054.1999","volume":"67","year":"1999","journal-title":"Infection and Immunity"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(02)01604-0"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2005.00609.x"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2266"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002760"},{"issue":"11","key":"21","doi-asserted-by":"crossref","first-page":"5485","DOI":"10.1128\/IAI.66.11.5485-5493.1998","volume":"66","year":"1998","journal-title":"Infection and Immunity"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-2508(00)90130-X"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-9-92"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.6.3261-3271.2003"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.11.6264-6269.2003"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.10.5716-5723.2000"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-009-0129-9"},{"issue":"8","key":"28","doi-asserted-by":"crossref","first-page":"3830","DOI":"10.1128\/IAI.67.8.3830-3835.1999","volume":"67","year":"1999","journal-title":"Infection and Immunity"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0307137101"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5462.2492"},{"issue":"8","key":"31","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1101\/gad.7.8.1485","volume":"7","year":"1993","journal-title":"Genes and Development"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1128\/JB.184.20.5625-5632.2002"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2005.04536.x"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M209389200"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00318-09"},{"issue":"5","key":"36","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1128\/IAI.56.5.1101-1106.1988","volume":"56","year":"1988","journal-title":"Infection and Immunity"},{"issue":"8","key":"37","doi-asserted-by":"crossref","first-page":"4701","DOI":"10.1128\/jb.172.8.4701-4704.1990","volume":"172","year":"1990","journal-title":"Journal of Bacteriology"},{"issue":"4","key":"38","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1099\/00221287-143-4-1115","volume":"143","year":"1997","journal-title":"Microbiology"},{"issue":"17","key":"39","doi-asserted-by":"crossref","first-page":"4392","DOI":"10.1128\/JB.180.17.4392-4400.1998","volume":"180","year":"1998","journal-title":"Journal of Bacteriology"},{"issue":"7","key":"40","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1099\/00221287-146-7-1735","volume":"146","year":"2000","journal-title":"Microbiology"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1128\/JB.186.21.7205-7213.2004"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwj113"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0708025104"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.4.2263-2271.2004"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00086-06"},{"issue":"4733","key":"46","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1126\/science.3941890","volume":"231","year":"1986","journal-title":"Science"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1998.00875.x"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.7.4528-4535.2001"},{"issue":"1","key":"49","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1128\/jb.168.1.270-275.1986","volume":"168","year":"1986","journal-title":"Journal of Bacteriology"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1038\/ni1202"},{"issue":"12","key":"51","doi-asserted-by":"crossref","first-page":"4403","DOI":"10.1073\/pnas.83.12.4403","volume":"83","year":"1986","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1993.tb00931.x"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1128\/JB.182.17.4849-4855.2000"},{"key":"54","first-page":"147","volume":"13","year":"1990","journal-title":"Advances in Biotechnological Processes"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2010.00211.x"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1135(02)00229-8"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.04.020"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1135(02)00255-9"},{"issue":"6","key":"59","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1136\/vr.81.6.140","volume":"81","year":"1967","journal-title":"Veterinary Record"},{"issue":"6","key":"60","first-page":"5","volume":"7","year":"1986","journal-title":"AGRI-PRACTICE"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002193"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1135(02)00231-6"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1051\/vetres:2003037"},{"issue":"11","key":"64","doi-asserted-by":"crossref","first-page":"6181","DOI":"10.1128\/IAI.67.11.6181-6186.1999","volume":"67","year":"1999","journal-title":"Infection and Immunity"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1135(91)90091-S"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.16.1.65-78.2003"}],"container-title":["International Journal of Microbiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijmicro\/2010\/124509.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijmicro\/2010\/124509.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijmicro\/2010\/124509.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,14]],"date-time":"2020-06-14T07:22:39Z","timestamp":1592119359000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/ijmicro\/2010\/124509\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":66,"alternative-id":["124509","124509"],"URL":"https:\/\/doi.org\/10.1155\/2010\/124509","relation":{},"ISSN":["1687-918X","1687-9198"],"issn-type":[{"value":"1687-918X","type":"print"},{"value":"1687-9198","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}