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We found significant differences in the levels of immunoglobulins, the C4 component of complement, the C\u2010reactive protein, interleukin 6, the composition of lymphocyte population and the production of some cytokines by stimulated CD3+ cells. Eleven of these patients were followed longitudinally. After treatment with hydroxyurea, interferon alpha, imatinib mesylate and dasatinib, or various combinations thereof, hematological remission was achieved in all patients and complete cytogenetic remission in nine of them. There was a nearly general tendency towards normalization of the abnormalities observed in the patients at their enrollment.<\/jats:p>","DOI":"10.1155\/2010\/137320","type":"journal-article","created":{"date-parts":[[2010,12,12]],"date-time":"2010-12-12T19:35:59Z","timestamp":1292182559000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Changes of Immunological Profiles in Patients with Chronic Myeloid Leukemia in the Course of Treatment"],"prefix":"10.1155","volume":"2010","author":[{"given":"Zuzana","family":"Humlov\u00e1","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hana","family":"Klamov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivana","family":"Janatkov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Mal\u00ed\u010dkov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"Kr\u00e1l\u00edkov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"\u0160terzl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zden\u011bk","family":"Roth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Ham\u0161\u00edkov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladim\u00edr","family":"Vonka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,12,12]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102133.1998.02486.x"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.74"},{"key":"e_1_2_7_3_2","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1182\/blood.V62.3.689.689","article-title":"Leukocyte interferon-induced myeloid cytoreduction in chronic myelogenous leukemia","volume":"62","author":"Talpaz M.","year":"1983","journal-title":"Blood"},{"key":"e_1_2_7_4_2","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1365-2141.1986.tb07576.x","article-title":"Chronic myelogenous leukaemia: haematological remissions with alpha interferon","volume":"64","author":"Talpaz M.","year":"1986","journal-title":"British Journal of Haematology"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.10.3074"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/79526"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102002\u201002\u20100659"},{"key":"e_1_2_7_8_2","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1172\/JCI10196","article-title":"Detection of a potent humoral response associated with immune-induced remission of chronic myelogenous leukemia","volume":"106","author":"Wu C. 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