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In addition, however, a series of other junction types has been identified and characterized which contain desmosomal molecules but do not fit the definition of desmosomes. Of these special cell\u2010cell junctions containing desmosomal glycoproteins or proteins we review the composite junctions (<jats:italic>areae compositae<\/jats:italic>) connecting the cardiomyocytes of mature mammalian hearts and their importance in relation to human arrhythmogenic cardiomyopathies. We also emphasize the various plakophilin\u20102\u2010positive plaques in AJs (<jats:italic>coniunctiones adhaerentes<\/jats:italic>) connecting proliferatively active mesenchymally\u2010derived cells, including interstitial cells of the heart and several soft tissue tumor cell types. Moreover, desmoplakin has also been recognized as a constituent of the plaques of the <jats:italic>complexus adhaerentes<\/jats:italic> connecting certain lymphatic endothelial cells. Finally, we emphasize the occurrence of the desmosomal transmembrane glycoprotein, desmoglein Dsg2, out of the context of any junction as dispersed cell surface molecules in certain types of melanoma cells and melanocytes. This broadening of our knowledge on the diversity of AJ structures indicates that it may still be too premature to close the textbook chapters on cell\u2010cell junctions.<\/jats:p>","DOI":"10.1155\/2010\/139167","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T15:13:50Z","timestamp":1277910830000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Desmosomal Molecules In and Out of Adhering Junctions: Normal and Diseased States of Epidermal, Cardiac and Mesenchymally Derived Cells"],"prefix":"10.1155","volume":"2010","author":[{"given":"Sebastian","family":"Pieperhoff","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mareike","family":"Barth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Rickelt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner W.","family":"Franke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,6,30]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.17.2.375"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.79.2.427"},{"key":"e_1_2_8_3_2","first-page":"427","volume-title":"The Cell in Contact","author":"Cowin P.","year":"1985"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-68170-0_6"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2007.07.014"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/9783527622092.ch12"},{"key":"e_1_2_8_7_2","series-title":"Cold Spring Harbor Perspectives in Biology","first-page":"1","volume-title":"Cell-Cell Junctions","author":"Franke W. 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