{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T18:16:28Z","timestamp":1759342588554,"version":"3.37.3"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["140475\/2000-1"],"award-info":[{"award-number":["140475\/2000-1"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biomedicine and Biotechnology"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>We investigated the antinociceptive and nerve excitability effects of the<jats:italic>N<\/jats:italic>-salicyloyltryptamine (NST) NST-treated mice exhibited a significant decrease in the number of writhes when 100 and 200\u2009mg\/kg (i.p.) were administered (i.p.). This effect was not antagonized by naloxone (1.5\u2009mg\/kg, i.p.). NST inhibited the licking response of the injected paw when 100 and 200\u2009mg\/kg were administered (i.p.) to mice in the first and second phases of the formalin test. Because the antinociceptive effects could be associated with neuronal excitability inhibition, we performed the single sucrose gap technique and showed that NST (3.57\u2009mM) significantly reduced (29.2%) amplitude of the compound action potential (CAP) suggesting a sodium channel effect induced by NST. Our results demonstrated an antinociceptive activity of the NST that could be, at least in part, associated to the reduction of the action potential amplitude. NST might represent an important tool for pain management.<\/jats:p>","DOI":"10.1155\/2010\/230745","type":"journal-article","created":{"date-parts":[[2010,10,5]],"date-time":"2010-10-05T15:45:08Z","timestamp":1286293508000},"page":"1-6","source":"Crossref","is-referenced-by-count":4,"title":["Bioassay-Guided Evaluation of Antinociceptive Effect of<i>N<\/i>-Salicyloyltryptamine: A Behavioral and Electrophysiological Approach"],"prefix":"10.1155","volume":"2010","author":[{"given":"Lucindo J.","family":"Quintans-J\u00fanior","sequence":"first","affiliation":[{"name":"Physiology Department, Federal University of Sergipe, \u201cProf. Alo\u00edsio de Campos\u201d University Campus, Av. Marechal Rondom, s\/n, CEP 49100-000 S\u00e3o Cristov\u00e3o, SE, Brazil"},{"name":"Pharmaceutical Technology Laboratory, Federal University of Paraiba, P.O. 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