{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T01:49:42Z","timestamp":1776476982964,"version":"3.51.2"},"reference-count":46,"publisher":"Wiley","license":[{"start":{"date-parts":[[2010,9,29]],"date-time":"2010-09-29T00:00:00Z","timestamp":1285718400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science, and Technology","doi-asserted-by":"crossref","award":["2010-0002054"],"award-info":[{"award-number":["2010-0002054"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Proteomics"],"published-print":{"date-parts":[[2010,9,29]]},"abstract":"<jats:p>Heat shock proteins (HSPs) have core housekeeping functions in the cells where they are built-in components of folding, signal transduction pathways, and quality control functions for which they proofread the structure of proteins and repair misfolded conformers. <jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>H. pylori<\/jats:italic>) infection leads to significant inflammations in the gastric mucosa, which is closely associated with development of either precancerous lesion including chronic atrophic gastritis or gastric cancer in addition to,  peptic ulcer disease, and mucosa-associated lymphoid tissue (MALT) lymphoma. Therefore, the association between <jats:italic>H. pylori<\/jats:italic> infection and role of HSP has been focused as an important issue because there had been rather conflicting publications showing that HSPs as a good worker for defense against <jats:italic>H. pylori<\/jats:italic> infection, whereas HSPs as a bad offender contributing to the progression of <jats:italic>H. pylori<\/jats:italic>-associated gastric carcinogenesis in addition to aggravation of gastric inflammation. In this paper regarding proteomic discovery of HSPs related to <jats:italic>H. pylori<\/jats:italic>-associated gastric diseases, we introduce several evidences obtained from proteomic analysis dealing with friend or foe role of HSP in <jats:italic>H. pylori<\/jats:italic> infection from a cellular level to human diseases. The implication of HSPs in alcoholic or NSAIDs-induced gastritis and the intervening of HSPs in biological changes exemplified with TGF-<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>\u03b2<\/mml:mi><\/mml:math> signaling, key tumor suppressor growth factors regulating inflammation, immune function, and carcinogenesis were further introduced.<\/jats:p>","DOI":"10.1155\/2010\/259163","type":"journal-article","created":{"date-parts":[[2010,9,30]],"date-time":"2010-09-30T06:14:10Z","timestamp":1285827250000},"page":"1-11","source":"Crossref","is-referenced-by-count":10,"title":["Heat Shock Protein: Hard Worker or Bad Offender for Gastric Diseases"],"prefix":"10.1155","volume":"2010","author":[{"given":"Ho-Jae","family":"Lee","sequence":"first","affiliation":[{"name":"Laboratory of Chemoprevention, Lee Gil Ya Cancer and Diabetes Institute, Gachon University of Medicine and Science, Incheon, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chan Young","family":"Ock","sequence":"additional","affiliation":[{"name":"Laboratory of Translational Medicine, Lee Gil Ya Cancer and Diabetes Institute, Gachon University of Medicine and Science, Incheon, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong-Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Regulation and Carcinogenesis, Lee Gil Ya Cancer and Diabetes Institute, Gachon University of Medicine and Science, Incheon, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki-Baik","family":"Hahm","sequence":"additional","affiliation":[{"name":"Laboratory of Translational Medicine, Lee Gil Ya Cancer and Diabetes Institute, Gachon University of Medicine and Science, Incheon, Republic of Korea"},{"name":"Department of Gastroenterology, Gachon Graduate School of Medicine Gil Medical Center, Songdo-dong 7-45, Yeonsu-gu, Incheon, 406-840, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80928-9"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.5427"},{"issue":"5","key":"3","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1152\/japplphysiol.01267.2001","volume":"92","year":"2002","journal-title":"Journal of Applied Physiology"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.01284"},{"issue":"11","key":"5","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1002\/j.1460-2075.1996.tb00630.x","volume":"15","year":"1996","journal-title":"EMBO Journal"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5378.2002.00048.x"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1038\/ncpgasthep1366"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.05.030"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-004-4464-6"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200400951"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2009.08.002"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2006.00383.x"},{"key":"13","first-page":"5","volume":"60","year":"2009","journal-title":"Journal of Physiology and Pharmacology"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2005.02.005"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.05.214"},{"issue":"3","key":"16","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1046\/j.1523-5378.1999.99295.x","volume":"4","year":"1999","journal-title":"Helicobacter"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2006.01.006"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1379\/CSC-99r.1"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1391.030"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.27.18947"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210395"},{"issue":"1","key":"22","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1136\/gut.45.1.20","volume":"45","year":"1999","journal-title":"Gut"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1097\/00001574-200201000-00004"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1007\/s12038-007-0051-y"},{"issue":"10","key":"25","first-page":"2111","volume":"55","year":"1995","journal-title":"Cancer Research"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01501-09"},{"issue":"2","key":"46","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.bbrc.2010.01.010","volume":"392","year":"2010","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"27","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1097\/00004836-198812001-00008","volume":"10","year":"1988","journal-title":"Journal of Clinical Gastroenterology"},{"issue":"3","key":"28","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/0016-5085(79)90002-7","volume":"77","year":"1979","journal-title":"Gastroenterology"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005615714451"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2003.11.016"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2005.03.027"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(01)01908-9"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2007.00302.x"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2008.05763.x"},{"issue":"11","key":"36","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1074\/mcp.T300007-MCP200","volume":"2","year":"2003","journal-title":"Molecular & Cellular Proteomics"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R800007200"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M412275200"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1379\/1466-1268(2003)008<0303:CALBTC>2.0.CO;2"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M600065-MCP200"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0800163105"},{"issue":"2","key":"41","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1177\/153537020322800201","volume":"228","year":"2003","journal-title":"Experimental Biology and Medicine"},{"issue":"1","key":"42","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.abb.2009.12.003","volume":"495","year":"2010","journal-title":"Archives of Biochemistry and Biophysics"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(02)00975-9"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00468.2007"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009050552"}],"container-title":["International Journal of Proteomics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/2010\/259163.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2010\/259163.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2010\/259163.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T04:11:00Z","timestamp":1607487060000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ijpro\/2010\/259163\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9,29]]},"references-count":46,"alternative-id":["259163","259163"],"URL":"https:\/\/doi.org\/10.1155\/2010\/259163","relation":{},"ISSN":["2090-2166","2090-2174"],"issn-type":[{"value":"2090-2166","type":"print"},{"value":"2090-2174","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,9,29]]}}}