{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T23:18:25Z","timestamp":1756682305145},"reference-count":19,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Thoracic Society of Australian and New Zealand"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tuberculosis Research and Treatment"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p><jats:italic>Aim<\/jats:italic>: To survey practices in the diagnosis and management of latent tuberculosis infection (LTBI) in Australia and New Zealand.<jats:italic>Methods<\/jats:italic>: Infectious diseases and respiratory physicians and trainees were invited to complete an online questionnaire concerning various aspects of LTBI management.<jats:italic>Results<\/jats:italic>: The questionnaire was completed by 126 clinicians self-reporting regular management of LTBI. Respondents were experienced physicians, with 95\/126 (75.4%) having managed LTBI for more than 5 years. Forty-seven (37.3%) reported seeing more than 5 patients per month for assessment of LTBI. Substantial variation among clinicians was reported in relation to a number of common clinical scenarios. For instance, while 52\/126 (43.7%) informed patients that the incidence of severe hepatotoxicity related to isoniazid monotherapy was 0.1\u20130.5%, 21\/126 (15.7%) thought it was<jats:italic>&gt;<\/jats:italic>5%. 36\/126 (28.6%) clinicians would proceed with TNF-<jats:italic><jats:italic>a<\/jats:italic><\/jats:italic>therapy following an indeterminate screening: interferon-<jats:italic><jats:italic>?<\/jats:italic><\/jats:italic>assay, while 78\/126 (61.9%) would perform further investigations and 12\/126 (9.5%) would initiate isoniazid therapy. Follow-up intervals during therapy varied from 1\u20133 monthly, with liver function testing performed routinely by 89\/126 (70.6%).<jats:italic>Conclusion<\/jats:italic>: This study demonstrated a large degree of variation in clinical practice of LTBI management in Australia and New Zealand. Strategies for increasing uniformity of practice are required, including improved guidelines and physician education.<\/jats:p>","DOI":"10.1155\/2010\/284028","type":"journal-article","created":{"date-parts":[[2010,12,29]],"date-time":"2010-12-29T19:37:48Z","timestamp":1293651468000},"page":"1-5","source":"Crossref","is-referenced-by-count":5,"title":["Management of Latent Tuberculosis Infections in Australia and New Zealand: A Review of Current Practice"],"prefix":"10.1155","volume":"2010","author":[{"given":"Justin T.","family":"Denholm","sequence":"first","affiliation":[{"name":"Victorian Infectious Diseases Service, Royal Melbourne Hospital, Grattan Street, Parkville, VIC, 3050, Australia"},{"name":"Department of Medicine, University of Melbourne, Parkville, VIC, 3010, Australia"},{"name":"Anton Breinl Centre, James Cook University, Townsville, QLd, 4810, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma S.","family":"McBryde","sequence":"additional","affiliation":[{"name":"Victorian Infectious Diseases Service, Royal Melbourne Hospital, Grattan Street, Parkville, VIC, 3050, Australia"},{"name":"Department of Medicine, University of Melbourne, Parkville, VIC, 3010, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.7.677"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp021045"},{"issue":"4","key":"3","first-page":"555","volume":"60","year":"1982","journal-title":"Bulletin of the World Health Organization"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2005.02.003"},{"key":"5","year":"2009"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.11.1014"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.1.116"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200510-1666ST"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken425"},{"key":"10","first-page":"1","volume":"73","year":"1956","journal-title":"The American Review of Tuberculosis and Pulmonary Diseases"},{"issue":"3","key":"11","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1164\/ajrccm.156.3.9609132","volume":"156","year":"1997","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31814523e4"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00145906"},{"issue":"rr15","key":"14","first-page":"49","volume":"54","year":"2005","journal-title":"MMWR"},{"key":"15","doi-asserted-by":"crossref","first-page":"S221","DOI":"10.1164\/ajrccm.161.supplement_3.ats600","volume":"161","year":"2000","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"16","year":"2006"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(04)01206-X"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002665"},{"issue":"12","key":"20","volume":"4","year":"2009","journal-title":"PloS One"}],"container-title":["Tuberculosis Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/trt\/2010\/284028.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/trt\/2010\/284028.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/trt\/2010\/284028.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T17:47:52Z","timestamp":1497894472000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/trt\/2010\/284028\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":19,"alternative-id":["284028","284028"],"URL":"https:\/\/doi.org\/10.1155\/2010\/284028","relation":{},"ISSN":["2090-150X","2090-1518"],"issn-type":[{"value":"2090-150X","type":"print"},{"value":"2090-1518","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}