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In relapsing and refractory PTCL several comparison analyses suggest similar efficacy for PTCL when compared with aggressive B-cell lymphoma. In the upfront setting, prospective data show promising results with a long-lasting overall survival in a relevant subset of patients. Achieving a complete remission at transplantation seems to be the most important prognostic factor. Allogeneic stem cell transplantation (alloSCT) has been investigated only as salvage treatment. Especially when using reduced intensity conditioning regimen, eligible patients seem to benefit from this approach. To define the role for upfront stem cell transplantation a randomised trial by the German High-Grade Non-Hodgkin Lymphoma Study Group comparing HDT-autoSCT and alloSCT will be initiated this year.<\/jats:p>","DOI":"10.1155\/2010\/320624","type":"journal-article","created":{"date-parts":[[2010,12,21]],"date-time":"2010-12-21T19:36:59Z","timestamp":1292960219000},"page":"1-12","source":"Crossref","is-referenced-by-count":30,"title":["Impact of Autologous and Allogeneic Stem Cell Transplantation in Peripheral T-Cell Lymphomas"],"prefix":"10.1155","volume":"2010","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5133-1094","authenticated-orcid":true,"given":"Peter","family":"Reimer","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr H\u00e4matologie, Internistische Onkologie und Stammzelltransplantation, Kliniken Essen S\u00fcd, Evangelisches Krankenhaus Essen-Werden gGmbH, Pattbergstra\u03b2e 1-3, 45239 Essen, 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