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Candidate gene polymorphism studies with a case-control design and reported genotype frequencies in CP patients were searched and reviewed. There is growing evidence that polymorphisms in the<jats:italic>IL1, IL6, IL10<\/jats:italic>, vitamin D receptor, and<jats:italic>CD14<\/jats:italic>genes may be associated with CP in certain populations. However, carriage rates of the rare -allele of any polymorphism varied considerably among studies and most of the studies appeared under-powered and did not correct for other risk factors. Larger cohorts, well-defined phenotypes, control for other risk factors, and analysis of multiple genes and polymorphisms within the same pathway are needed to get a more comprehensive insight into the contribution of gene polymorphisms in CP.<\/jats:p>","DOI":"10.1155\/2010\/324719","type":"journal-article","created":{"date-parts":[[2010,2,9]],"date-time":"2010-02-09T15:30:56Z","timestamp":1265729456000},"page":"1-22","source":"Crossref","is-referenced-by-count":88,"title":["Gene Polymorphisms in Chronic Periodontitis"],"prefix":"10.1155","volume":"2010","author":[{"given":"Marja L.","family":"Laine","sequence":"first","affiliation":[{"name":"Department of Oral Microbiology, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije University, 1081 BT Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno G.","family":"Loos","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Academic Center 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