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The inflammatory periapical reaction is mainly driven by Th1, Th2, and Th17 responses, and such polarization may modulate progression of the disease and expression of bone proresorptive cytokines. IL\u201012 is a potent inducer of IFN\u2010<jats:italic>\u03b3<\/jats:italic> production, which stimulates Th1 effector cells. Many evidences have shown a positive correlation between the bone resorptive cytokine IL\u20101<jats:italic>\u03b2<\/jats:italic> and the production of IL\u201012 and IFN\u2010<jats:italic>\u03b3<\/jats:italic>. Furthermore, IL\u201012 may have a potential role in the release of bone resorptive mediators and blockade of Th2 cytokines, affecting the progression of periapical bone loss. Nevertheless, IL\u201012 and IFN\u2010<jats:italic>\u03b3<\/jats:italic> have also been described as suppressors of osteoclast differentiation and activation, favoring bone maintenance. This paper focuses on the controversial roles of IL\u201012 in periapical lesions.<\/jats:p>","DOI":"10.1155\/2010\/327417","type":"journal-article","created":{"date-parts":[[2011,2,16]],"date-time":"2011-02-16T21:32:11Z","timestamp":1297891931000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["A Controversial Role for IL\u201012 in Immune Response and Bone Resorption at Apical Periodontal Sites"],"prefix":"10.1155","volume":"2010","author":[{"given":"Celso Martins","family":"Queiroz-Junior","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Jos\u00e9 Barbosa","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f4ice Dias","family":"Corr\u00eaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mila Fernandes Moreira","family":"Madeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago Pompermaier","family":"Garlet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Pompermaier","family":"Garlet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Queiroz","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro Martins","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarc\u00edlia Aparecida da","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,2,16]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.9.5650\u20105660.2001"},{"key":"e_1_2_8_2_2","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/jlb.59.4.505","article-title":"Immunoregulation by interleukin-12","volume":"59","author":"Trinchieri G.","year":"1996","journal-title":"Journal of Leukocyte Biology"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074\u20107613(03)00296\u20106"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2010.01.004"},{"key":"e_1_2_8_5_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2478\/v10039-010-0037-0","article-title":"IL-8, IL-12 and IL-10 cytokines generation by neutrophils, fibroblasts and neutrophils-fibroblasts interaction in psoriasis","volume":"55","author":"Glowacka A.","year":"2010","journal-title":"Advances in Medical Sciences"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0b013e328339d099"},{"key":"e_1_2_8_7_2","doi-asserted-by":"crossref","first-page":"6193","DOI":"10.4049\/jimmunol.180.9.6193","article-title":"T cell response mediated by myeloid cell-derived IL-12 is responsible for Porphyromonas gingivalis-induced periodontitis in IL-10-deficient mice","volume":"180","author":"Sasaki H.","year":"2008","journal-title":"Journal of Immunology"},{"key":"e_1_2_8_8_2","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1600-0757.1997.tb00098.x","article-title":"Apical periodontitis: a dynamic encounter between root canal infection and host response","volume":"14","author":"Nair P. 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