{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T05:12:20Z","timestamp":1740287540128,"version":"3.37.3"},"reference-count":71,"publisher":"Wiley","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advances in Hematology"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>Multiple myeloma is an incurable disease, although patient survival has increased with the availability of novel agents. Both multiple myeloma and its therapies often affect the renal, immune, skeletal, hematologic, and nervous systems. The resulting organ dysfunctions often impair the quality of life of affected patients, complicate and limit subsequent therapies, and may result in significant mortality. Research on the treatment of complications of multiple myeloma has been limited; hence, preventative and management strategies for patients with these complications are heterogeneous and often based on anecdotal experience. In this paper, we review the effects of myeloma and the novel therapies on organ systems and suggest management strategies.<\/jats:p>","DOI":"10.1155\/2010\/343089","type":"journal-article","created":{"date-parts":[[2010,6,27]],"date-time":"2010-06-27T14:35:53Z","timestamp":1277649353000},"page":"1-8","source":"Crossref","is-referenced-by-count":3,"title":["State-of-the-Art Management of Complications of Myeloma and Its Treatment"],"prefix":"10.1155","volume":"2010","author":[{"given":"Monique A.","family":"Hartley-Brown","sequence":"first","affiliation":[{"name":"Blood and Marrow Transplant Department, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Dr, Tampa, FL 33612, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2183-1773","authenticated-orcid":true,"given":"Daniel M.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Blood and Marrow Transplant Department, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Dr, Tampa, FL 33612, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachid","family":"Baz","sequence":"additional","affiliation":[{"name":"Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Dr, Tampa, FL 33612, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.02.116"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-07-2817"},{"key":"3","first-page":"190","volume":"1","year":"2003","journal-title":"Clinical Advances in Hematology & Oncology"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032290"},{"issue":"18s","key":"5","volume":"25","year":"2007","journal-title":"Journal of Clinical Oncology"},{"issue":"3","key":"6","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1002\/1097-0142(197509)36:3<842::AID-CNCR2820360303>3.0.CO;2-U","volume":"36","year":"1975","journal-title":"Cancer"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/S0268-960X(99)90014-0"},{"issue":"4, article e60","key":"8","volume":"89","year":"2004","journal-title":"Haematologica"},{"issue":"4-5","key":"9","first-page":"169","volume":"55","year":"2001","journal-title":"Acta medica Croatica"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-03-1186"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-10-4278"},{"issue":"5","key":"12","first-page":"398","volume":"56","year":"2001","journal-title":"Clinical Nephrology"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.108"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.150.4.863"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.10.1351"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-9-55"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.11-7-824"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705395"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06191.x"},{"issue":"23","key":"20","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1056\/NEJM198006053022305","volume":"302","year":"1980","journal-title":"The New England Journal of Medicine"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0b013e32801494c6"},{"issue":"2","key":"22","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0002-9343(76)90440-X","volume":"60","year":"1976","journal-title":"American Journal of Medicine"},{"issue":"3-4","key":"23","first-page":"235","volume":"37","year":"1989","journal-title":"Acta Morphologica Hungarica"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2006.069104"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2003.08.040"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2003.09.020"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(95)00043-7"},{"issue":"18s","key":"28","volume":"25","year":"2007","journal-title":"Journal of Clinical Oncology"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0801479"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90180-5"},{"issue":"7","key":"31","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1054\/bjoc.1999.1088","volume":"82","year":"2000","journal-title":"British Journal of Cancer"},{"key":"32","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.1182\/blood.V112.11.2772.2772","volume":"112","year":"2008","journal-title":"Blood"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc051795"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc051795"},{"key":"35","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1182\/blood.V112.11.2613.2613","volume":"112","year":"2008","journal-title":"Blood"},{"issue":"1","key":"36","first-page":"29","volume":"50","year":"1975","journal-title":"Mayo Clinic Proceedings"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06491.x"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.00.8581"},{"issue":"3","key":"39","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1148\/radiology.134.3.7355226","volume":"134","year":"1980","journal-title":"Radiology"},{"issue":"10","key":"40","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1002\/jbmr.5650101008","volume":"10","year":"1995","journal-title":"Journal of Bone and Mineral Research"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199602223340802"},{"issue":"2","key":"42","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1200\/JCO.2001.19.2.558","volume":"19","year":"2001","journal-title":"Journal of Clinical Oncology"},{"issue":"12","key":"43","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.14219\/jada.archive.2005.0108","volume":"136","year":"2005","journal-title":"Journal of the American Dental Association"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.60.063007.134350"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.06.037"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.3816\/SCT.2006.n.026"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.12.11.1377"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1172\/JCI34734"},{"issue":"4","key":"49","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/01.NCC.0000305734.80592.40","volume":"31","year":"2008","journal-title":"Cancer Nursing"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(99)00304-8"},{"issue":"2","key":"51","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1148\/radiographics.18.2.9536480","volume":"18","year":"1998","journal-title":"Radiographics"},{"issue":"2","key":"52","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1148\/radiology.200.2.8685351","volume":"200","year":"1996","journal-title":"Radiology"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200107150-00026"},{"key":"54","doi-asserted-by":"crossref","first-page":"S176","DOI":"10.1097\/01.blo.0000093841.72468.a8","volume":"415","year":"2003","journal-title":"Clinical Orthopaedics and Related Research"},{"issue":"3","key":"55","first-page":"358","volume":"5","year":"2003","journal-title":"Ortopedia Traumatologia Rehabilitacja"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20405"},{"issue":"12","key":"57","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.4065\/80.12.1568","volume":"80","year":"2005","journal-title":"Mayo Clinic Proceedings"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1586\/14737140.7.3.307"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.0221"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-200204000-00003"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2405062"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-117457"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20441"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2005.01.024"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-04-149385"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07573.x"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.05.6689"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.123"},{"issue":"8","key":"70","first-page":"249","volume":"61","year":"2003","journal-title":"Netherlands Journal of Medicine"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2004.05.001"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1007\/BF00400603"}],"container-title":["Advances in Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ah\/2010\/343089.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ah\/2010\/343089.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ah\/2010\/343089.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T08:29:50Z","timestamp":1740212990000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/ah\/2010\/343089\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":71,"alternative-id":["343089","343089"],"URL":"https:\/\/doi.org\/10.1155\/2010\/343089","relation":{},"ISSN":["1687-9104","1687-9112"],"issn-type":[{"type":"print","value":"1687-9104"},{"type":"electronic","value":"1687-9112"}],"subject":[],"published":{"date-parts":[[2010]]}}}