{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:14:11Z","timestamp":1753881251004,"version":"3.41.2"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,1,13]],"date-time":"2011-01-13T00:00:00Z","timestamp":1294876800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p>Researchers have suggested that the fate of a shock\u2010induced wave front at the\nedge of a \u201cvirtual anode\u201d (a region hyperpolarized by the shock) is a key factor determining success or failure during defibrillation of the heart. In this paper, we use a simple one\u2010dimensional computer model to examine propagation speed through a hyperpolarized region. Our goal is to test the hypothesis that rapid propagation through a virtual anode can cause failure of propagation at the edge of the virtual anode. The calculations support this hypothesis and suggest that the time constant of the sodium inactivation gate is an important parameter. These results may be significant in understanding the mechanism of the upper limit of vulnerability.<\/jats:p>","DOI":"10.1155\/2010\/375059","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T07:19:32Z","timestamp":1718695172000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["How Hyperpolarization and the Recovery of Excitability Affect Propagation through a Virtual Anode in the Heart"],"prefix":"10.1155","volume":"2011","author":[{"given":"Nicholas P.","family":"Charteris","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley J.","family":"Roth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,13]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2000.tb00173.x"},{"key":"e_1_2_6_2_2","first-page":"527","article-title":"Le seuil de r\u00e9ponse synchrone des fibres myocardiques. 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